Angiotensin receptor signaling in sickle cell anemia has a reno-protective effect on urine concentrating ability but results in sickle glomerulopathy.

Roy, Swarnava; Rai, Parul; Eiymo Mwa Mpollo, Marthe-Sandrine; Chang, Kyung-Hee; Rizvi, Tilat; Shanmukhappa, Shiva Kumar; VandenHeuvel, Katherine; Aronow, Bruce; Inagami, Tadashi; Cancelas, Jose A; Malik, Punam

Roy, Swarnava; Rai, Parul; Eiymo Mwa Mpollo, Marthe-Sandrine; Chang, Kyung-Hee; Rizvi, Tilat; Shanmukhappa, Shiva Kumar; VandenHeuvel, Katherine; Aronow, Bruce; Inagami, Tadashi; Cancelas, Jose A; Malik, Punam.

Afiliação

Roy S; Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children's Research Foundation, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 45229.
Rai P; Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children's Research Foundation, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 45229.
Eiymo Mwa Mpollo MS; Division of Hematology, Cancer and Blood Diseases Institute, Hoxworth Blood Center, Cincinnati, Ohio, 45267.
Chang KH; Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children's Research Foundation, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 45229.
Rizvi T; Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children's Research Foundation, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 45229.
Shanmukhappa SK; Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children's Research Foundation, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 45229.
VandenHeuvel K; Division of Pathology, Cincinnati Children's Research Foundation, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 45229.
Aronow B; Division of Pathology, Cincinnati Children's Research Foundation, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 45229.
Inagami T; Division of Bioinformatics, Cincinnati Children's Research Foundation, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 45229.
Cancelas JA; Vanderbilt University School of Medicine, Nashville, Tennessee.
Malik P; Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children's Research Foundation, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 45229.

Am J Hematol ; 93(7): E177-E181, 2018 07.

Article em En | MEDLINE | ID: mdl-29675906

Assuntos

Anemia Falciforme/metabolismo; Capacidade de Concentração Renal; Nefropatias/etiologia; Receptores de Angiotensina/metabolismo; Adulto; Anemia Falciforme/complicações; Bloqueadores do Receptor Tipo 1 de Angiotensina II/uso terapêutico; Animais; Captopril/farmacologia; Criança; Progressão da Doença; Humanos; Losartan/farmacologia; Camundongos; Substâncias Protetoras; Receptor Tipo 2 de Angiotensina/agonistas; Transdução de Sinais

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores de Angiotensina / Anemia Falciforme / Capacidade de Concentração Renal / Nefropatias Limite: Adult / Animals / Child / Humans Idioma: En Revista: Am J Hematol Ano de publicação: 2018 Tipo de documento: Article

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