Renal safety of short-term empiric gentamicin therapy in aged patients.
Australas J Ageing
; 37(3): 227-231, 2018 Sep.
Article
em En
| MEDLINE
| ID: mdl-29704297
ABSTRACT
OBJECTIVE:
To determine the incidence of acute kidney injury (AKI) in aged patients receiving empiric gentamicin therapy.METHODS:
Patients aged ≥65 years receiving gentamicin upon admission between 2013 and 2015 at two Australian hospitals were retrospectively studied. AKI was defined as a rise in creatinine by ≥50% and/or ≥26.5 µmol/L.RESULTS:
Most patients (95%) received a single dose of gentamicin. The incidence of AKI was 15% (36/242 patients). A composite outcome of persistent kidney injury, requirement for renal replacement therapy or inpatient death in a patient with AKI occurred in 10 (4%) patients. Patients who developed AKI were older (median 80.5 vs 78 years, P = 0.03), had higher Charlson Co-morbidity Index (median 7 vs 5, P = 0.0004) and had more advanced chronic kidney disease at baseline (Stages IV and V) (OR 4.38, 95% confidence interval 1.45-13.2, P = 0.01).CONCLUSION:
Empiric gentamicin use in patients with advancing age is associated with low rates of predominantly transient renal impairment.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Gentamicinas
/
Injúria Renal Aguda
/
Rim
/
Antibacterianos
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
País/Região como assunto:
Oceania
Idioma:
En
Revista:
Australas J Ageing
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Austrália