Reciprocal loop of hypoxia-inducible factor-1&#945; (HIF-1&#945;) and metastasis-associated protein 2 (MTA2) contributes to the progression of pancreatic carcinoma by suppressing E-cadherin transcription.

Zhu, Shuai; Deng, Shijiang; He, Chi; Liu, Mingliang; Chen, Hengyu; Zeng, Zhu; Zhong, Jianxin; Ye, Zeng; Deng, Shichang; Wu, Heshui; Wang, Chunyou; Zhao, Gang

Reciprocal loop of hypoxia-inducible factor-1α (HIF-1α) and metastasis-associated protein 2 (MTA2) contributes to the progression of pancreatic carcinoma by suppressing E-cadherin transcription.

Zhu, Shuai; Deng, Shijiang; He, Chi; Liu, Mingliang; Chen, Hengyu; Zeng, Zhu; Zhong, Jianxin; Ye, Zeng; Deng, Shichang; Wu, Heshui; Wang, Chunyou; Zhao, Gang.

Afiliação

Zhu S; Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, PR China.
Deng S; Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, PR China.
He C; Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, PR China.
Liu M; Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, PR China.
Chen H; Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, PR China.
Zeng Z; Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, PR China.
Zhong J; Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, PR China.
Ye Z; Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, PR China.
Deng S; Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, PR China.
Wu H; Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, PR China.
Wang C; Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, PR China.
Zhao G; Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, PR China.

J Pathol ; 245(3): 349-360, 2018 07.

Article em En | MEDLINE | ID: mdl-29708271

Assuntos

Adenocarcinoma/metabolismo; Antígenos CD/metabolismo; Caderinas/metabolismo; Histona Desacetilases/metabolismo; Subunidade alfa do Fator 1 Induzível por Hipóxia/metabolismo; Neoplasias Pancreáticas/metabolismo; Proteínas Repressoras/metabolismo; Acetilação; Adenocarcinoma/genética; Adenocarcinoma/secundário; Animais; Antígenos CD/genética; Caderinas/genética; Linhagem Celular Tumoral; Movimento Celular; Proliferação de Células; Regulação para Baixo; Transição Epitelial-Mesenquimal; Feminino; Regulação Neoplásica da Expressão Gênica; Histona Desacetilase 1/metabolismo; Histona Desacetilases/genética; Humanos; Subunidade alfa do Fator 1 Induzível por Hipóxia/genética; Camundongos Endogâmicos BALB C; Invasividade Neoplásica; Neoplasias Pancreáticas/genética; Neoplasias Pancreáticas/patologia; Processamento de Proteína Pós-Traducional; Estabilidade Proteica; Proteínas Repressoras/genética; Elementos de Resposta; Transdução de Sinais; Transcrição Gênica; Carga Tumoral

Palavras-chave

E-cadherin; HIF-1α; MTA2; hypoxia; pancreatic carcinoma

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Proteínas Repressoras / Adenocarcinoma / Antígenos CD / Caderinas / Subunidade alfa do Fator 1 Induzível por Hipóxia / Histona Desacetilases Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Female / Humans Idioma: En Revista: J Pathol Ano de publicação: 2018 Tipo de documento: Article

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