The intranuclear PEX domain of MMP involves proliferation, migration, and metastasis of aggressive adenocarcinoma cells.

Okusha, Yuka; Eguchi, Takanori; Sogawa, Chiharu; Okui, Tatsuo; Nakano, Keisuke; Okamoto, Kuniaki; Kozaki, Ken-Ichi

Okusha, Yuka; Eguchi, Takanori; Sogawa, Chiharu; Okui, Tatsuo; Nakano, Keisuke; Okamoto, Kuniaki; Kozaki, Ken-Ichi.

Afiliação

Okusha Y; Department of Dental Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Eguchi T; Department of Dental Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Sogawa C; Advanced Research Center for Oral and Craniofacial Sciences, Graduate School of Medicine, Dentistry andPharmaceutical Sciences, Okayama University, Okayama, Japan.
Okui T; Department of Dental Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Nakano K; Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Okamoto K; Advanced Research Center for Oral and Craniofacial Sciences, Graduate School of Medicine, Dentistry andPharmaceutical Sciences, Okayama University, Okayama, Japan.
Kozaki KI; Department of Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.

J Cell Biochem ; 119(9): 7363-7376, 2018 09.

Article em En | MEDLINE | ID: mdl-29761931

Assuntos

Adenocarcinoma/patologia; Neoplasias do Colo/patologia; Hemopexina/metabolismo; Metaloproteinase 3 da Matriz/genética; Metaloproteinase 3 da Matriz/metabolismo; Metaloproteinase 9 da Matriz/genética; Metaloproteinase 9 da Matriz/metabolismo; Aloenxertos/metabolismo; Análise de Variância; Animais; Linhagem Celular Tumoral; Movimento Celular; Proliferação de Células; Expressão Gênica; Técnicas de Silenciamento de Genes; Neoplasias Pulmonares/patologia; Camundongos; Camundongos Endogâmicos BALB C; Invasividade Neoplásica; Metástase Neoplásica

Palavras-chave

PEX domain; cancer metastasis; non-proteolytic MMP; nuclear MMP; tumor stroma

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hemopexina / Adenocarcinoma / Neoplasias do Colo / Metaloproteinase 3 da Matriz / Metaloproteinase 9 da Matriz Limite: Animals Idioma: En Revista: J Cell Biochem Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Japão

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