Molecular Mechanisms of Fast Neurotransmitter Release.
Annu Rev Biophys
; 47: 469-497, 2018 05 20.
Article
em En
| MEDLINE
| ID: mdl-29792815
This review summarizes current knowledge of synaptic proteins that are central to synaptic vesicle fusion in presynaptic active zones, including SNAREs (soluble N-ethylmaleimide sensitive factor attachment protein receptors), synaptotagmin, complexin, Munc18 (mammalian uncoordinated-18), and Munc13 (mammalian uncoordinated-13), and highlights recent insights in the cooperation of these proteins for neurotransmitter release. Structural and functional studies of the synaptic fusion machinery suggest new molecular models of synaptic vesicle priming and Ca2+-triggered fusion. These studies will be a stepping-stone toward answering the question of how the synaptic vesicle fusion machinery achieves such high speed and sensitivity.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transmissão Sináptica
/
Neurotransmissores
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Annu Rev Biophys
Assunto da revista:
BIOFISICA
Ano de publicação:
2018
Tipo de documento:
Article