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Loss of USP28-mediated BRAF degradation drives resistance to RAF cancer therapies.
Saei, Azad; Palafox, Marta; Benoukraf, Touati; Kumari, Nishi; Jaynes, Patrick William; Iyengar, Prasanna Vasudevan; Muñoz-Couselo, Eva; Nuciforo, Paolo; Cortés, Javier; Nötzel, Christopher; Kumarakulasinghe, Nesaretnam Barr; Richard, John Lalith Charles; Bin Adam Isa, Zul Fazreen; Pang, Brendan; Guzman, Marta; Siqin, Zhou; Yang, Henry; Tam, Wai Leong; Serra, Violeta; Eichhorn, Pieter Johan Adam.
Afiliação
  • Saei A; Genome Institute of Singapore, A*STAR, Singapore, Singapore.
  • Palafox M; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  • Benoukraf T; Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.
  • Kumari N; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
  • Jaynes PW; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  • Iyengar PV; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
  • Muñoz-Couselo E; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
  • Nuciforo P; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
  • Cortés J; Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.
  • Nötzel C; Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.
  • Kumarakulasinghe NB; Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.
  • Richard JLC; Cancer Ramon y Cajal University Hospital, Madrid, Spain.
  • Bin Adam Isa ZF; IOB Institute of Oncology, Quironsalud group, Madrid & Barcelona, Spain.
  • Pang B; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
  • Guzman M; Department of Hematology-Oncology, National University Cancer Institute, Singapore, National University Health System, Singapore, Singapore.
  • Siqin Z; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
  • Yang H; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
  • Tam WL; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
  • Serra V; Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.
  • Eichhorn PJA; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
J Exp Med ; 215(7): 1913-1928, 2018 07 02.
Article em En | MEDLINE | ID: mdl-29880484

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Resistencia a Medicamentos Antineoplásicos / Ubiquitina Tiolesterase / Proteínas Proto-Oncogênicas B-raf / Proteólise / Melanoma Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Exp Med Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Singapura

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Resistencia a Medicamentos Antineoplásicos / Ubiquitina Tiolesterase / Proteínas Proto-Oncogênicas B-raf / Proteólise / Melanoma Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Exp Med Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Singapura