Halloysite clay nanotubes for life sciences applications: From drug encapsulation to bioscaffold.
Adv Colloid Interface Sci
; 257: 58-70, 2018 Jul.
Article
em En
| MEDLINE
| ID: mdl-29887382
ABSTRACT
Natural forming clay halloysite is an emerging nanomaterial carrier for sustained drug delivery. These 50â¯nm diameter aluminosilicate tubes, with inner - alumina and outer - silica surface layers, can be loaded with 10-30â¯wt% of drug molecules, DNA and enzymes. The opposite charge of the inner and outer halloysite surface allow for selective drug adsorption inside or outside the clay nanotubes. The drug loaded halloysite enhanced the zeta potential of minus 50-60â¯mV allowing for stable aqueous nanocolloids. Halloysite nanoformulations provide an extended 10-20â¯h release profile, and may be functionalized (e.g., clogging tubes' end with polymers extending release time to 1-2â¯weeks or allowing for triggered release), which renders these clay nanostructures as promising controlled delivery systems. Recent studies demonstrate the potential of abundantly available halloysite clay nanotubes for life science applications, from drug delivery via oral or topical administration, to tissue scaffolds and regenerative medicine, while assessing their cellular internalization, stability, biosafety and biocompatibility are featured. The benefits and limitations of halloysite clay nanotubes are discussed, as well as the directions for future developments.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Materiais Biocompatíveis
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Preparações Farmacêuticas
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Sistemas de Liberação de Medicamentos
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Nanotubos
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Composição de Medicamentos
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Alicerces Teciduais
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Silicatos de Alumínio
Limite:
Animals
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Humans
Idioma:
En
Revista:
Adv Colloid Interface Sci
Assunto da revista:
QUIMICA
Ano de publicação:
2018
Tipo de documento:
Article