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Intensive care doctors' preferences for arterial oxygen tension levels in mechanically ventilated patients.
Schjørring, O L; Toft-Petersen, A P; Kusk, K H; Mouncey, P; Sørensen, E E; Berezowicz, P; Bestle, M H; Bülow, H-H; Bundgaard, H; Christensen, S; Iversen, S A; Kirkeby-Garstad, I; Krarup, K B; Kruse, M; Laake, J H; Liboriussen, L; Laebel, R L; Okkonen, M; Poulsen, L M; Russell, L; Sjövall, F; Sunde, K; Søreide, E; Waldau, T; Walli, A R; Perner, A; Wetterslev, J; Rasmussen, B S.
Afiliação
  • Schjørring OL; Department of Anaesthesia and Intensive Care Medicine, Aalborg University Hospital, Aalborg, Denmark.
  • Toft-Petersen AP; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
  • Kusk KH; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
  • Mouncey P; Intensive Care National Audit & Research Centre (ICNARC), London, UK.
  • Sørensen EE; Clinical Nursing Research Unit, Aalborg University Hospital, Aalborg, Denmark.
  • Berezowicz P; Intensive Care National Audit & Research Centre (ICNARC), London, UK.
  • Bestle MH; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
  • Bülow HH; Clinical Nursing Research Unit, Aalborg University Hospital, Aalborg, Denmark.
  • Bundgaard H; Department of Anaesthesia and Intensive Care Medicine, Vejle Hospital, Vejle, Denmark.
  • Christensen S; Department of Anaesthesia and Intensive Care Medicine, Nordsjaellands Hospital, Hillerød, Denmark.
  • Iversen SA; Department of Anaesthesia and Intensive Care Medicine, Holbaek Hospital, Holbaek, Denmark.
  • Kirkeby-Garstad I; Department of Anaesthesia and Intensive Care, Randers Hospital, Randers, Denmark.
  • Krarup KB; Department of Anaesthesia and Intensive Care Medicine, Aarhus University Hospital, Skejby, Denmark.
  • Kruse M; Department of Anaesthesia and Intensive Care Medicine, Slagelse Hospital, Slagelse, Denmark.
  • Laake JH; Department of Anaesthesia and Intensive Care Medicine, St. Olav's Hospital, Trondheim, Norway.
  • Liboriussen L; Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
  • Laebel RL; Department of Anaesthesia and Intensive Care, Odense University Hospital, Odense, Denmark.
  • Okkonen M; Department of Anaesthesia and Intensive Care, North Denmark Regional Hospital, Hjørring, Denmark.
  • Poulsen LM; Division of Emergencies and Critical Care, Rikshospitalet, Oslo University Hospital, Oslo, Norway.
  • Russell L; Department of Anaesthesia and Intensive Care Medicine, Viborg Hospital, Viborg, Denmark.
  • Sjövall F; Department of Anaesthesia and Intensive Care Medicine, Regional Hospital West Jutland, Herning, Denmark.
  • Sunde K; Department of Perioperative, Intensive Care and Pain Medicine, Helsinki University Hospital, Helsinki, Finland.
  • Søreide E; Department of Anaesthesia and Intensive Care Medicine, Zealand University Hospital, Køge, Denmark.
  • Waldau T; Department of Anaesthesia and Intensive Care Medicine, Hvidovre Hospital, Hvidovre, Denmark.
  • Walli AR; Department of Intensive Care and Perioperative Medicine, Skåne University Hospital, Malmö, Sweden.
  • Perner A; Department of Clinical Science, Lund University, Lund, Sweden.
  • Wetterslev J; Department of Anaeshesiology, Oslo University Hospital, Ullevål, Norway.
  • Rasmussen BS; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Acta Anaesthesiol Scand ; 62(10): 1443-1451, 2018 11.
Article em En | MEDLINE | ID: mdl-29926908
BACKGROUND: Oxygen is liberally administered in intensive care units (ICUs). Nevertheless, ICU doctors' preferences for supplementing oxygen are inadequately described. The aim was to identify ICU doctors' preferences for arterial oxygenation levels in mechanically ventilated adult ICU patients. METHODS: In April to August 2016, an online multiple-choice 17-part-questionnaire was distributed to 1080 ICU doctors in seven Northern European countries. Repeated reminder e-mails were sent. The study ended in October 2016. RESULTS: The response rate was 63%. When evaluating oxygenation 52% of respondents rated arterial oxygen tension (PaO2 ) the most important parameter; 24% a combination of PaO2 and arterial oxygen saturation (SaO2 ); and 23% preferred SaO2 . Increasing, decreasing or not changing a default fraction of inspired oxygen of 0.50 showed preferences for a PaO2 around 8 kPa in patients with chronic obstructive pulmonary disease, a PaO2 around 10 kPa in patients with healthy lungs, acute respiratory distress syndrome or sepsis, and a PaO2 around 12 kPa in patients with cardiac or cerebral ischaemia. Eighty per cent would accept a PaO2 of 8 kPa or lower and 77% would accept a PaO2 of 12 kPa or higher in a clinical trial of oxygenation targets. CONCLUSION: Intensive care unit doctors preferred PaO2 to SaO2 in monitoring oxygen treatment when peripheral oxygen saturation was not included in the question. The identification of PaO2 as the preferred target and the thorough clarification of preferences are important when ascertaining optimal oxygenation targets. In particular when designing future clinical trials of higher vs lower oxygenation targets in ICU patients.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oxigênio / Respiração Artificial / Unidades de Terapia Intensiva Tipo de estudo: Clinical_trials Limite: Humans Idioma: En Revista: Acta Anaesthesiol Scand Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Dinamarca

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oxigênio / Respiração Artificial / Unidades de Terapia Intensiva Tipo de estudo: Clinical_trials Limite: Humans Idioma: En Revista: Acta Anaesthesiol Scand Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Dinamarca