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EVI1 carboxy-terminal phosphorylation is ATM-mediated and sustains transcriptional modulation and self-renewal via enhanced CtBP1 association.
Paredes, Roberto; Schneider, Marion; Stevens, Adam; White, Daniel J; Williamson, Andrew J K; Muter, Joanne; Pearson, Stella; Kelly, James R; Connors, Kathleen; Wiseman, Daniel H; Chadwick, John A; Löffler, Harald; Teng, Hsiang Ying; Lovell, Simon; Unwin, Richard; van de Vrugt, Henri J; Smith, Helen; Kustikova, Olga; Schambach, Axel; Somervaille, Tim C P; Pierce, Andrew; Whetton, Anthony D; Meyer, Stefan.
Afiliação
  • Paredes R; Stem Cell and Leukaemia Proteomics Laboratory, Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Palatine Road, Manchester M20 3LI, UK.
  • Schneider M; Manchester Academic Health Science Centre, Manchester, UK.
  • Stevens A; Stem Cell and Leukaemia Proteomics Laboratory, Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Palatine Road, Manchester M20 3LI, UK.
  • White DJ; Manchester Academic Health Science Centre, Manchester, UK.
  • Williamson AJK; Manchester Academic Health Science Centre, Manchester, UK.
  • Muter J; Division of Developmental Biology and Medicine, Faculty of Biology, Medicine and Health M13 9WL, University of Manchester, UK.
  • Pearson S; Stem Cell and Leukaemia Proteomics Laboratory, Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Palatine Road, Manchester M20 3LI, UK.
  • Kelly JR; Manchester Academic Health Science Centre, Manchester, UK.
  • Connors K; Stem Cell and Leukaemia Proteomics Laboratory, Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Palatine Road, Manchester M20 3LI, UK.
  • Wiseman DH; Manchester Academic Health Science Centre, Manchester, UK.
  • Chadwick JA; Stem Cell and Leukaemia Proteomics Laboratory, Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Palatine Road, Manchester M20 3LI, UK.
  • Löffler H; Manchester Academic Health Science Centre, Manchester, UK.
  • Teng HY; Stem Cell and Leukaemia Proteomics Laboratory, Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Palatine Road, Manchester M20 3LI, UK.
  • Lovell S; Manchester Academic Health Science Centre, Manchester, UK.
  • Unwin R; Stem Cell and Leukaemia Proteomics Laboratory, Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Palatine Road, Manchester M20 3LI, UK.
  • van de Vrugt HJ; Manchester Academic Health Science Centre, Manchester, UK.
  • Smith H; Stem Cell and Leukaemia Proteomics Laboratory, Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Palatine Road, Manchester M20 3LI, UK.
  • Kustikova O; Manchester Academic Health Science Centre, Manchester, UK.
  • Schambach A; Manchester Academic Health Science Centre, Manchester, UK.
  • Somervaille TCP; Leukaemia Biology Group, CRUK Manchester Institute, Manchester M20 4XB, UK.
  • Pierce A; Manchester Academic Health Science Centre, Manchester, UK.
  • Whetton AD; Leukaemia Biology Group, CRUK Manchester Institute, Manchester M20 4XB, UK.
  • Meyer S; Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ) and Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.
Nucleic Acids Res ; 46(15): 7662-7674, 2018 09 06.
Article em En | MEDLINE | ID: mdl-29939287
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regulação Leucêmica da Expressão Gênica / Proteínas de Ligação a DNA / Oxirredutases do Álcool / Proteínas Mutadas de Ataxia Telangiectasia / Autorrenovação Celular / Proteína do Locus do Complexo MDS1 e EVI1 Tipo de estudo: Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Nucleic Acids Res Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regulação Leucêmica da Expressão Gênica / Proteínas de Ligação a DNA / Oxirredutases do Álcool / Proteínas Mutadas de Ataxia Telangiectasia / Autorrenovação Celular / Proteína do Locus do Complexo MDS1 e EVI1 Tipo de estudo: Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Nucleic Acids Res Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Reino Unido