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Vitamin D replacement ameliorates serum lipoprotein functions, adipokine profile and subclinical atherosclerosis in pre-menopausal women.
Greco, D; Kocyigit, D; Adorni, M P; Marchi, C; Ronda, N; Bernini, F; Gurses, K M; Canpinar, H; Guc, D; Oguz, S H; Gurlek, A; Strazzella, A; Simonelli, S; Tokgozoglu, L; Zimetti, F.
Afiliação
  • Greco D; Biopharmanet-Tec Center, University of Parma, Parma, Italy.
  • Kocyigit D; Department of Cardiology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
  • Adorni MP; Department of Food and Drug, University of Parma, Parma, Italy.
  • Marchi C; Department of Food and Drug, University of Parma, Parma, Italy.
  • Ronda N; Department of Food and Drug, University of Parma, Parma, Italy.
  • Bernini F; Department of Food and Drug, University of Parma, Parma, Italy. Electronic address: fbernini@unipr.it.
  • Gurses KM; Department of Cardiology, University of Health Sciences, Konya Training and Research Hospital, Konya, Turkey.
  • Canpinar H; Department of Basic Oncology, Hacettepe University Cancer Institute, Ankara, Turkey.
  • Guc D; Department of Basic Oncology, Hacettepe University Cancer Institute, Ankara, Turkey.
  • Oguz SH; Department of Internal Medicine, Section of Endocrinology and Metabolism, Hacettepe University Faculty of Medicine, Ankara, Turkey.
  • Gurlek A; Department of Internal Medicine, Section of Endocrinology and Metabolism, Hacettepe University Faculty of Medicine, Ankara, Turkey.
  • Strazzella A; Centro E. Grossi Paoletti, Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milano, Italy.
  • Simonelli S; Centro E. Grossi Paoletti, Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milano, Italy.
  • Tokgozoglu L; Department of Cardiology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
  • Zimetti F; Department of Food and Drug, University of Parma, Parma, Italy.
Nutr Metab Cardiovasc Dis ; 28(8): 822-829, 2018 08.
Article em En | MEDLINE | ID: mdl-29954641
BACKGROUND AND AIMS: Low vitamin D (vitD) has been linked to increased cardiovascular (CV) risk, but the effects of vitD supplementation are not clarified. We evaluated the impact of vitD normalization on HDL cholesterol efflux capacity (CEC), which inversely correlates with CV risk, the proatherogenic serum cholesterol loading capacity (CLC), adipokine profile and subclinical atherosclerosis. METHODS AND RESULTS: Healthy premenopausal women with vitD deficiency (n = 31) underwent supplementation. Subclinical atherosclerosis was evaluated by flow-mediated dilation (FMD), pulse wave velocity (PWV) and augmentation index (AIx), measured with standard techniques. HDL CEC and serum CLC were measured by a radioisotopic and fluorimetric assay, respectively. Malondialdehyde (MDA) in HDL was quantified by the TBARS assay. Pre-ß HDL was assessed by 2D-electrophoresis. Serum adipokines were measured by ELISA. VitD replacement restored normal levels of serum 25-hydroxyvitamin D (25OHD) and significantly improved FMD (+4%; p < 0.001), PWV (-4.1%: p < 0.001) and AIx (-16.1%; p < 0.001). Total CEC was significantly improved (+19.5%; p = 0.003), with a specific increase in the ABCA1-mediated CEC (+70.8%; p < 0.001). HDL-MDA slightly but significantly decreased (-9.6%; p = 0.027), while no difference was detected in pre-ß HDL. No change was observed in aqueous diffusion nor in the ABCG1-mediated CEC. Serum CLC was significantly reduced (-13.3%; p = 0.026). Levels of adiponectin were increased (+50.6%; p < 0.0001) and resistin levels were decreased (-24.3%; p < 0.0001). After vitD replacement, an inverse relationship was found linking the ABCA1-mediated CEC with pre-ß HDL (r2 = 0.346; p < 0.001) and resistin (r2 = 0.220; p = 0.009). CONCLUSION: Our data support vitD supplementation for CV risk prevention.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Deficiência de Vitamina D / Pré-Menopausa / Colecalciferol / Suplementos Nutricionais / Aterosclerose / Lipoproteínas de Alta Densidade Pré-beta / Adipocinas / HDL-Colesterol Tipo de estudo: Diagnostic_studies / Etiology_studies / Prognostic_studies Limite: Adult / Female / Humans País/Região como assunto: Asia Idioma: En Revista: Nutr Metab Cardiovasc Dis Assunto da revista: ANGIOLOGIA / CARDIOLOGIA / CIENCIAS DA NUTRICAO / METABOLISMO Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Itália

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Deficiência de Vitamina D / Pré-Menopausa / Colecalciferol / Suplementos Nutricionais / Aterosclerose / Lipoproteínas de Alta Densidade Pré-beta / Adipocinas / HDL-Colesterol Tipo de estudo: Diagnostic_studies / Etiology_studies / Prognostic_studies Limite: Adult / Female / Humans País/Região como assunto: Asia Idioma: En Revista: Nutr Metab Cardiovasc Dis Assunto da revista: ANGIOLOGIA / CARDIOLOGIA / CIENCIAS DA NUTRICAO / METABOLISMO Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Itália