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Monitoring of Osteonecrosis in Systemic Lupus Erythematosus: A Systematic Review and Metaanalysis.
Hussein, Sara; Suitner, Manon; Béland-Bonenfant, Sarah; Baril-Dionne, Alexandra; Vandermeer, Ben; Santesso, Nancy; Keeling, Stephanie; Pope, Janet E; Fifi-Mah, Aurore; Bourré-Tessier, Josiane.
Afiliação
  • Hussein S; From the Department of Medicine, University of Montréal, Montréal, Quebec; Alberta Research Center, and Department of Medicine, University of Alberta, Edmonton, Alberta; Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton; Department of Medicine, Western University o
  • Suitner M; S. Hussein, MD, Rheumatology Resident, Department of Medicine, University of Montreal; M. Suitner, MD, Rheumatology Resident, Department of Medicine, University of Montreal; S. Béland-Bonenfant, MD, Internal Medicine Resident, Department of Medicine, University of Montreal; A. Baril-Dionne, MD, Rheu
  • Béland-Bonenfant S; From the Department of Medicine, University of Montréal, Montréal, Quebec; Alberta Research Center, and Department of Medicine, University of Alberta, Edmonton, Alberta; Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton; Department of Medicine, Western University o
  • Baril-Dionne A; S. Hussein, MD, Rheumatology Resident, Department of Medicine, University of Montreal; M. Suitner, MD, Rheumatology Resident, Department of Medicine, University of Montreal; S. Béland-Bonenfant, MD, Internal Medicine Resident, Department of Medicine, University of Montreal; A. Baril-Dionne, MD, Rheu
  • Vandermeer B; From the Department of Medicine, University of Montréal, Montréal, Quebec; Alberta Research Center, and Department of Medicine, University of Alberta, Edmonton, Alberta; Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton; Department of Medicine, Western University o
  • Santesso N; S. Hussein, MD, Rheumatology Resident, Department of Medicine, University of Montreal; M. Suitner, MD, Rheumatology Resident, Department of Medicine, University of Montreal; S. Béland-Bonenfant, MD, Internal Medicine Resident, Department of Medicine, University of Montreal; A. Baril-Dionne, MD, Rheu
  • Keeling S; From the Department of Medicine, University of Montréal, Montréal, Quebec; Alberta Research Center, and Department of Medicine, University of Alberta, Edmonton, Alberta; Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton; Department of Medicine, Western University o
  • Pope JE; S. Hussein, MD, Rheumatology Resident, Department of Medicine, University of Montreal; M. Suitner, MD, Rheumatology Resident, Department of Medicine, University of Montreal; S. Béland-Bonenfant, MD, Internal Medicine Resident, Department of Medicine, University of Montreal; A. Baril-Dionne, MD, Rheu
  • Fifi-Mah A; From the Department of Medicine, University of Montréal, Montréal, Quebec; Alberta Research Center, and Department of Medicine, University of Alberta, Edmonton, Alberta; Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton; Department of Medicine, Western University o
  • Bourré-Tessier J; S. Hussein, MD, Rheumatology Resident, Department of Medicine, University of Montreal; M. Suitner, MD, Rheumatology Resident, Department of Medicine, University of Montreal; S. Béland-Bonenfant, MD, Internal Medicine Resident, Department of Medicine, University of Montreal; A. Baril-Dionne, MD, Rheu
J Rheumatol ; 45(10): 1462-1476, 2018 10.
Article em En | MEDLINE | ID: mdl-29961688
ABSTRACT

OBJECTIVE:

Nontraumatic osteonecrosis (ON) is a well-recognized complication causing disability and affecting quality of life in patients with systemic lupus erythematosus (SLE). The aim of this study was to identify the risk factors for ON, and to identify the minimal investigation(s) needed to optimally monitor the risk of ON in patients with SLE.

METHODS:

A systematic review was conducted using MEDLINE and EMBASE. These databases were searched up to January 2016 using the Medical Subject Heading (MeSH) terms "Osteonecrosis," "Systemic lupus erythematosus," and synonymous text words. Randomized controlled trials, case control, cohort, and cross-sectional studies were included. Risk factors for ON in patients with SLE were compiled. The quality of each study was assessed using the Newcastle-Ottawa scale for nonrandomized studies. The quality of evidence of each risk factor was assessed using the Grading of Recommendations, Assessment, Development, and Evaluation method.

RESULTS:

Of the 545 references yielded, 50 met inclusion criteria. Corticosteroid (CS) use may be strongly associated with ON in patients with SLE. Other clinical variables were moderately associated, including hypertension, serositis, renal disease, vasculitis, arthritis, and central nervous system disease. However, the evidence was low to very low in quality.

CONCLUSION:

Based on the best evidence available, CS use may be strongly associated with ON in patients with SLE. Results of this review were considered in the development of recommendations for the diagnosis and monitoring of patients with SLE in Canada and will guide clinicians in their assessment of these patients.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteonecrose / Corticosteroides / Lúpus Eritematoso Sistêmico Tipo de estudo: Clinical_trials / Etiology_studies / Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Humans País/Região como assunto: America do norte Idioma: En Revista: J Rheumatol Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteonecrose / Corticosteroides / Lúpus Eritematoso Sistêmico Tipo de estudo: Clinical_trials / Etiology_studies / Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Humans País/Região como assunto: America do norte Idioma: En Revista: J Rheumatol Ano de publicação: 2018 Tipo de documento: Article