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Multiparametric quantitative MRI assessment of thigh muscles in limb-girdle muscular dystrophy 2A and 2B.
Arrigoni, Filippo; De Luca, Alberto; Velardo, Daniele; Magri, Francesca; Gandossini, Sandra; Russo, Annamaria; Froeling, Martijn; Bertoldo, Alessandra; Leemans, Alexander; Bresolin, Nereo; D'angelo, Grazia.
Afiliação
  • Arrigoni F; Neuroimaging Lab, Scientific Institute, IRCCS E. Medea, Via don L. Monza 20, Bosisio Parini, Italy.
  • De Luca A; Image Sciences Institute, University Medical Center Utrecht and University Utrecht, Utrecht, The Netherlands.
  • Velardo D; NeuroMuscular Unit, Scientific Institute, IRCCS E. Medea, Bosisio Parini, Italy.
  • Magri F; Neurology Unit, IRCCS Foundation Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.
  • Gandossini S; NeuroMuscular Unit, Scientific Institute, IRCCS E. Medea, Bosisio Parini, Italy.
  • Russo A; NeuroMuscular Unit, Scientific Institute, IRCCS E. Medea, Bosisio Parini, Italy.
  • Froeling M; NeuroMuscular Unit, Scientific Institute, IRCCS E. Medea, Bosisio Parini, Italy.
  • Bertoldo A; Department of Information Engineering, Padova University, Padova, Italy.
  • Leemans A; Image Sciences Institute, University Medical Center Utrecht and University Utrecht, Utrecht, The Netherlands.
  • Bresolin N; Neurology Unit, IRCCS Foundation Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.
  • D'angelo G; NeuroMuscular Unit, Scientific Institute, IRCCS E. Medea, Bosisio Parini, Italy.
Muscle Nerve ; 58(4): 550-558, 2018 10.
Article em En | MEDLINE | ID: mdl-30028523
ABSTRACT

INTRODUCTION:

The aim of this study was to apply quantitative MRI (qMRI) to assess structural modifications in thigh muscles of subjects with limb girdle muscular dystrophy (LGMD) 2A and 2B with long disease duration.

METHODS:

Eleven LGMD2A, 9 LGMD2B patients and 11 healthy controls underwent a multi-parametric 3T MRI examination of the thigh. The protocol included structural T1-weighted images, DIXON sequences for fat fraction calculation, T2 values quantification and diffusion MRI. Region of interest analysis was performed on 4 different compartments (anterior compartment, posterior compartment, gracilis, sartorius).

RESULTS:

Patients showed high levels of fat infiltration as measured by DIXON sequences. Sartorius and anterior compartment were more infiltrated in LGMD2B than LGMD2A patients. T2 values were mildly reduced in both disorders. Correlations between clinical scores and qMRI were found.

CONCLUSIONS:

qMRI measures may help to quantify muscular degeneration, but careful interpretation is needed when fat infiltration is massive. Muscle Nerve 58 550-558, 2018.
Assuntos
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tecido Adiposo / Distrofia Muscular do Cíngulo dos Membros / Músculo Quadríceps / Músculos Isquiossurais Tipo de estudo: Guideline / Observational_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Muscle Nerve Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Itália

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tecido Adiposo / Distrofia Muscular do Cíngulo dos Membros / Músculo Quadríceps / Músculos Isquiossurais Tipo de estudo: Guideline / Observational_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Muscle Nerve Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Itália