Papio spp. Colon microbiome and its link to obesity in pregnancy.
J Med Primatol
; 47(6): 393-401, 2018 12.
Article
em En
| MEDLINE
| ID: mdl-30039863
ABSTRACT
INTRODUCTION:
Gut microbial communities are critical players in the pathogenesis of obesity. Pregnancy is associated with increased bacterial load and changes in gut bacterial diversity. Sparse data exist regarding composition of gut microbial communities in obesity combined with pregnancy. MATERIAL ANDMETHODS:
Banked tissues were collected under sterile conditions during necropsy, from three non-obese (nOb) and four obese (Ob) near-term pregnant baboons. Sequences were assigned taxonomy using the Ribosomal Database Project classifier. Microbiome abundance and its difference between distinct groups were assessed by a nonparametric test.RESULTS:
Three families predominated in both the nOb and Ob colonic microbiome Prevotellaceae (25.98% and 32.71% respectively), Ruminococcaceae (12.96% and 7.48%), and Lachnospiraceae (8.78% and 11.74%). Seven families of the colon microbiome displayed differences between Ob and nOb groups.CONCLUSION:
Changes in gut microbiome in pregnant obese animals open the venue for dietary manipulation in pregnancy.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Papio
/
Bactérias
/
Microbioma Gastrointestinal
/
Doenças dos Macacos
/
Obesidade
Limite:
Animals
/
Pregnancy
Idioma:
En
Revista:
J Med Primatol
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Dinamarca