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Augmented Zika and Dengue Neutralizing Antibodies Are Associated With Guillain-Barré Syndrome.
Lynch, Rebecca M; Mantus, Grace; Encinales, Liliana; Pacheco, Nelly; Li, Guangzhao; Porras, Alexandra; Mendoza, Alejandro R; Peng, Jin; Rengifo-Pardo, Monica; Cruz, Magelda Montoya; Harris, Eva; Bethony, Jeff M; Simon, Gary L; Chang, Aileen Y.
Afiliação
  • Lynch RM; Department of Microbiology, Immunology, and Tropical Medicine, George Washington University, Washington, District of Columbia.
  • Mantus G; Department of Microbiology, Immunology, and Tropical Medicine, George Washington University, Washington, District of Columbia.
  • Encinales L; Department of Medicine, Allied Research Society LLC, Baranquilla.
  • Pacheco N; Department of Medicine, Allied Research Society LLC, Baranquilla.
  • Li G; Department of Microbiology, Immunology, and Tropical Medicine, George Washington University, Washington, District of Columbia.
  • Porras A; Grupo de Medicina Comunitaria, Universidad El Bosque, Bogotá, Colombia.
  • Mendoza AR; Grupo de Medicina Comunitaria, Universidad El Bosque, Bogotá, Colombia.
  • Peng J; Department of Microbiology, Immunology, and Tropical Medicine, George Washington University, Washington, District of Columbia.
  • Rengifo-Pardo M; Department of Dermatology, George Washington University, Washington, District of Columbia.
  • Cruz MM; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley.
  • Harris E; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley.
  • Bethony JM; Department of Microbiology, Immunology, and Tropical Medicine, George Washington University, Washington, District of Columbia.
  • Simon GL; Department of Medicine, George Washington University, Washington, District of Columbia.
  • Chang AY; Department of Medicine, George Washington University, Washington, District of Columbia.
J Infect Dis ; 219(1): 26-30, 2019 01 01.
Article em En | MEDLINE | ID: mdl-30113672
ABSTRACT
The role of neutralizing antibodies in Zika-induced Guillain-Barré syndrome (GBS) has not yet been investigated. We conducted a case-control study using sera from the 2016 Zika epidemic in Colombia to determine the neutralizing antibody activity against Zika virus (ZIKV) and dengue virus serotype 2 (DENV2). We observed increased neutralizing antibody titers against DENV2 in ZIKV-infected individuals compared with uninfected controls and higher titers to both ZIKV and DENV2 in ZIKV-infected patients diagnosed with GBS compared with non-GBS ZIKV-infected controls. These data suggest that high neutralizing antibody titers to DENV and to ZIKV are associated with GBS during ZIKV infection.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome de Guillain-Barré / Dengue / Anticorpos Neutralizantes / Infecção por Zika virus / Anticorpos Antivirais Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Colombia Idioma: En Revista: J Infect Dis Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome de Guillain-Barré / Dengue / Anticorpos Neutralizantes / Infecção por Zika virus / Anticorpos Antivirais Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Colombia Idioma: En Revista: J Infect Dis Ano de publicação: 2019 Tipo de documento: Article