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Can Bile Salt Export Pump Inhibition Testing in Drug Discovery and Development Reduce Liver Injury Risk? An International Transporter Consortium Perspective.
Kenna, J Gerry; Taskar, Kunal S; Battista, Christina; Bourdet, David L; Brouwer, Kim L R; Brouwer, Kenneth R; Dai, David; Funk, Christoph; Hafey, Michael J; Lai, Yurong; Maher, Jonathan; Pak, Y Anne; Pedersen, Jenny M; Polli, Joseph W; Rodrigues, A David; Watkins, Paul B; Yang, Kyunghee; Yucha, Robert W.
Afiliação
  • Kenna JG; Safer Medicines Trust, Kingsbridge, UK.
  • Taskar KS; Mechanistic Safety and Disposition, IVIVT, GlaxoSmithKline, Ware, Hertfordshire, UK.
  • Battista C; DILIsym Services Inc., a Simulations Plus Company, Research Triangle Park, North Carolina, USA.
  • Bourdet DL; Drug Metabolism and Pharmacokinetics, Theravance Biopharma, South San Francisco, California, USA.
  • Brouwer KLR; Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
  • Brouwer KR; ADME-TOX, BioIVT, Durham, North Carolina, USA.
  • Dai D; Clinical Pharmacology, Research and Development Sciences, Agios Pharmaceuticals, Cambridge, Massachusetts, USA.
  • Funk C; Roche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, Basel, Switzerland.
  • Hafey MJ; Department of Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Inc, Kenilworth, New Jersey, USA.
  • Lai Y; Drug Metabolism, Gilead Sciences Inc., Foster City, California, USA.
  • Maher J; Safety Assessment, Genentech, South San Francisco, California, USA.
  • Pak YA; Lilly Research Laboratory, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, Indiana, USA.
  • Pedersen JM; Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Novum, Huddinge, Sweden.
  • Polli JW; Mechanistic Safety and Drug Disposition, GlaxoSmithKline, King of Prussia, Pennsylvania, USA.
  • Rodrigues AD; PDM, Medicine Design, Pfizer Inc., Groton, Connecticut, USA.
  • Watkins PB; Institute for Drug Safety Sciences, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, USA.
  • Yang K; DILIsym Services Inc., a Simulations Plus Company, Research Triangle Park, North Carolina, USA.
  • Yucha RW; Takeda Pharmaceuticals, Global Drug Metabolism and Pharmacokinetics, Cambridge, Massachusetts, USA.
Clin Pharmacol Ther ; 104(5): 916-932, 2018 11.
Article em En | MEDLINE | ID: mdl-30137645
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bile / Moduladores de Transporte de Membrana / Descoberta de Drogas / Doença Hepática Induzida por Substâncias e Drogas / Membro 11 da Subfamília B de Transportadores de Cassetes de Ligação de ATP / Desenvolvimento de Medicamentos / Fígado Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Clin Pharmacol Ther Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bile / Moduladores de Transporte de Membrana / Descoberta de Drogas / Doença Hepática Induzida por Substâncias e Drogas / Membro 11 da Subfamília B de Transportadores de Cassetes de Ligação de ATP / Desenvolvimento de Medicamentos / Fígado Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Clin Pharmacol Ther Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Reino Unido