Rivaroxaban and macitentan can be coadministered without dose adjustment but the combination of rivaroxaban and St John's wort should be avoided.

Huppertz, Andrea; Werntz, Lars; Meid, Andreas D; Foerster, Kathrin I; Burhenne, Jürgen; Czock, David; Mikus, Gerd; Haefeli, Walter E

Huppertz, Andrea; Werntz, Lars; Meid, Andreas D; Foerster, Kathrin I; Burhenne, Jürgen; Czock, David; Mikus, Gerd; Haefeli, Walter E.

Afiliação

Huppertz A; Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
Werntz L; Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
Meid AD; Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
Foerster KI; Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
Burhenne J; Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
Czock D; Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
Mikus G; Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
Haefeli WE; Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.

Br J Clin Pharmacol ; 84(12): 2903-2913, 2018 12.

Article em En | MEDLINE | ID: mdl-30192025

Assuntos

Hypericum; Pirimidinas/administração & dosagem; Rivaroxabana/administração & dosagem; Sulfonamidas/administração & dosagem; Adulto; Área Sob a Curva; Citocromo P-450 CYP3A/fisiologia; Interações Medicamentosas; Quimioterapia Combinada; Feminino; Humanos; Masculino; Pessoa de Meia-Idade; Cooperação do Paciente; Pirimidinas/farmacocinética; Rivaroxabana/farmacocinética; Sulfonamidas/farmacocinética

Palavras-chave

Saint John's wort; macitentan; pharmacokinetic interaction; rivaroxaban

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinas / Sulfonamidas / Hypericum / Rivaroxabana Tipo de estudo: Prognostic_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Br J Clin Pharmacol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Alemanha

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