SETD2 in MLL-rearranged leukemia - a complex case.

Skucha, Anna; Ebner, Jessica; Grebien, Florian

Skucha, Anna; Ebner, Jessica; Grebien, Florian.

Afiliação

Skucha A; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Ebner J; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.
Grebien F; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.

Mol Cell Oncol ; 5(4): e1503492, 2018.

Article em En | MEDLINE | ID: mdl-30250934

ABSTRACT

ABSTRACT

Oncogenic MLL-fusion proteins often hijack essential molecular mechanisms during leukemogenesis. The histone methyltransferase SETD2 was implicated in the regulation of transcription, DNA damage and other cellular processes. Recent studies identified a critical role for SETD2 in MLL-rearranged leukemia. These results may help to unravel important functions of SETD2 in hematopoiesis.

Palavras-chave

AML; MLL-rearranged leukemia; SETD2; fusion proteins

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Mol Cell Oncol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Áustria

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google