Role of nuclear receptor coregulators in metabolism.
Expert Rev Endocrinol Metab
; 2(6): 797-807, 2007 Nov.
Article
em En
| MEDLINE
| ID: mdl-30290475
ABSTRACT
Understanding the molecular regulation of metabolism will lead to a better understanding of the pathogenesis and treatment of common metabolic conditions, including obesity and diabetes. Nuclear receptors are a family of transcription factors, many of which play major roles in regulating metabolic genes in key tissues. They function by recruiting coregulators to the promoters of metabolic genes that can either activate or repress transcription. This review examines the roles of these coregulators in the control of metabolism in adipose tissue and skeletal muscle, and discusses how they result in coordinated and regulated control of metabolic pathways. In particular, the ligand-dependent recruitment of both coactivators and corepressors has potential implications for the treatment of obesity and diabetes.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Expert Rev Endocrinol Metab
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Reino Unido