The relationship between oxytocin, dietary intake and feeding: A systematic review and meta-analysis of studies in mice and rats.
Front Neuroendocrinol
; 52: 65-78, 2019 01.
Article
em En
| MEDLINE
| ID: mdl-30315826
ABSTRACT
The neuropeptide oxytocin has been associated with food intake and feeding behaviour. This systematic review aimed to investigate the impact of oxytocin on dietary intake and feeding behaviour in rodent studies. Six electronic databases were searched to identify published studies to April 2018. Preclinical studies in mice and rats were included if they reported (1) a dietary measure (i.e. food or nutrient and/or behaviour (2) an oxytocin measure, and (3) relationship between the two measures. A total of 75 articles (nâ¯=â¯246 experiments) were included, and study quality appraised. The majority of studies were carried out in males (87%). The top three oxytocin outcomes assessed were exogenous oxytocin administration (nâ¯=â¯126), oxytocin-receptor antagonist administration (nâ¯=â¯46) and oxytocin gene deletion (nâ¯=â¯29). Meta-analysis of exogenous studies in mice (3 studies, nâ¯=â¯43 comparisons) and rats (nâ¯=â¯8 studies, nâ¯=â¯82 comparisons) showed an overall decrease in food intake with maximum effect shown at 2â¯h post-administration.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ocitocina
/
Ingestão de Alimentos
/
Comportamento Alimentar
Tipo de estudo:
Systematic_reviews
Limite:
Animals
Idioma:
En
Revista:
Front Neuroendocrinol
Ano de publicação:
2019
Tipo de documento:
Article