Phosphorylation of TRIM28 Enhances the Expression of IFN-ß and Proinflammatory Cytokines During HPAIV Infection of Human Lung Epithelial Cells.

Krischuns, Tim; Günl, Franziska; Henschel, Lea; Binder, Marco; Willemsen, Joschka; Schloer, Sebastian; Rescher, Ursula; Gerlt, Vanessa; Zimmer, Gert; Nordhoff, Carolin; Ludwig, Stephan; Brunotte, Linda

Krischuns, Tim; Günl, Franziska; Henschel, Lea; Binder, Marco; Willemsen, Joschka; Schloer, Sebastian; Rescher, Ursula; Gerlt, Vanessa; Zimmer, Gert; Nordhoff, Carolin; Ludwig, Stephan; Brunotte, Linda.

Afiliação

Krischuns T; Institute of Virology Muenster, Westfaelische Wilhelms-University Muenster, Muenster, Germany.
Günl F; Cluster of Excellence "Cells in Motion", Westfaelische Wilhelms-University Muenster, Muenster, Germany.
Henschel L; Institute of Virology Muenster, Westfaelische Wilhelms-University Muenster, Muenster, Germany.
Binder M; Cluster of Excellence "Cells in Motion", Westfaelische Wilhelms-University Muenster, Muenster, Germany.
Willemsen J; Institute of Virology Muenster, Westfaelische Wilhelms-University Muenster, Muenster, Germany.
Schloer S; Cluster of Excellence "Cells in Motion", Westfaelische Wilhelms-University Muenster, Muenster, Germany.
Rescher U; Research Group "Dynamics of Early Viral Infection and the Innate Antiviral Response", Division Virus-Associated Carcinogenesis (F170), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Gerlt V; Research Group "Dynamics of Early Viral Infection and the Innate Antiviral Response", Division Virus-Associated Carcinogenesis (F170), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Zimmer G; Cluster of Excellence "Cells in Motion", Westfaelische Wilhelms-University Muenster, Muenster, Germany.
Nordhoff C; Center for Molecular Biology of Inflammation, Institute of Medical Biochemistry, Westfaelische Wilhelms-University Muenster, Muenster, Germany.
Ludwig S; Cluster of Excellence "Cells in Motion", Westfaelische Wilhelms-University Muenster, Muenster, Germany.
Brunotte L; Center for Molecular Biology of Inflammation, Institute of Medical Biochemistry, Westfaelische Wilhelms-University Muenster, Muenster, Germany.

Front Immunol ; 9: 2229, 2018.

Article em En | MEDLINE | ID: mdl-30323812

Assuntos

Células Epiteliais/virologia; Vírus da Influenza A/metabolismo; Influenza Humana/metabolismo; Interferon beta/metabolismo; Pulmão/virologia; Proteína 28 com Motivo Tripartido/genética; Proteína 28 com Motivo Tripartido/metabolismo; Células A549; Análise de Variância; Animais; Sistemas CRISPR-Cas/genética; Chlorocebus aethiops; Proteína DEAD-box 58/metabolismo; Técnicas de Silenciamento de Genes; Técnicas de Transferência de Genes; Células HEK293; Células Endoteliais da Veia Umbilical Humana; Humanos; Fosforilação; Receptores Imunológicos; Proteínas Quinases S6 Ribossômicas 90-kDa/metabolismo; Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo

Palavras-chave

IFN-ß; KAP1; PKR; RIG-I; TIF1-beta; TRIM28; influenza; innate immunity

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus da Influenza A / Interferon beta / Células Epiteliais / Influenza Humana / Proteína 28 com Motivo Tripartido / Pulmão Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Front Immunol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Alemanha

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