Non-invasive assessment of disease progression and neuroprotective effects of dietary coconut oil supplementation in the ALS SOD1<sup>G93A</sup> mouse model: A <sup>1</sup>H-magnetic resonance spectroscopic study.

Weerasekera, A; Sima, D M; Dresselaers, T; Van Huffel, S; Van Damme, P; Himmelreich, U

Non-invasive assessment of disease progression and neuroprotective effects of dietary coconut oil supplementation in the ALS SOD1^G93A mouse model: A ¹H-magnetic resonance spectroscopic study.

Weerasekera, A; Sima, D M; Dresselaers, T; Van Huffel, S; Van Damme, P; Himmelreich, U.

Afiliação

Weerasekera A; Biomedical MRI Unit/MoSAIC, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium.
Sima DM; Department of Electrical Engineering (ESAT), STADIUS Center for Dynamical Systems, Signal Processing and Data Analytics, KU Leuven, Leuven, Belgium; icometrix, R&D department, Leuven, Belgium.
Dresselaers T; Radiology, Department of Imaging and Pathology, UZ Leuven, Leuven, Belgium.
Van Huffel S; Department of Electrical Engineering (ESAT), STADIUS Center for Dynamical Systems, Signal Processing and Data Analytics, KU Leuven, Leuven, Belgium.
Van Damme P; Department of Neurology, University Hospitals Leuven, Laboratory of Neurobiology, Leuven, Belgium; Department of Neurosciences, KU Leuven, Center for Brain & Disease Research, VIB, Leuven, Belgium.
Himmelreich U; Biomedical MRI Unit/MoSAIC, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium. Electronic address: uwe.himmelreich@kuleuven.be.

Neuroimage Clin ; 20: 1092-1105, 2018.

Article em En | MEDLINE | ID: mdl-30368196

Assuntos

Esclerose Lateral Amiotrófica/tratamento farmacológico; Esclerose Lateral Amiotrófica/patologia; Óleo de Coco/farmacologia; Progressão da Doença; Esclerose Lateral Amiotrófica/fisiopatologia; Animais; Comportamento Animal/efeitos dos fármacos; Comportamento Animal/fisiologia; Modelos Animais de Doenças; Imageamento por Ressonância Magnética/métodos; Espectroscopia de Ressonância Magnética/métodos; Camundongos Transgênicos; Fármacos Neuroprotetores; Medula Espinal/patologia

Palavras-chave

Amyotrophic lateral sclerosis; Brain metabolism; Coconut oil; Creatine; Magnetic resonance spectroscopy; SOD1G93A

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Progressão da Doença / Óleo de Coco / Esclerose Lateral Amiotrófica Tipo de estudo: Screening_studies Limite: Animals Idioma: En Revista: Neuroimage Clin Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Bélgica

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