A clinical and immunological study of phototoxic regimen of ultraviolet A for treatment of alopecia areata: a randomized controlled clinical trial.
J Dermatolog Treat
; 30(6): 582-587, 2019 Sep.
Article
em En
| MEDLINE
| ID: mdl-30411986
ABSTRACT
Background:
Various therapeutic agents have been described for alopecia areata but none is satisfactory. The use of ultraviolet A phototherapy in phototoxic regimens has emerged lately with promising results.Objective:
To determine the efficacy and safety of phototoxic regimen of psoralen ultraviolet A (PUVA) in comparison to conventional therapy with intralesional corticosteroids in patients with alopecia areata.Methods:
In this randomized controlled clinical trial, 40 patients were randomized to either phototoxic regimen of psoralen ultraviolet A group or potent intralesional corticosteroids group for three months. Study ended at six months. The primary outcome was treatment success sustained regrowth of hair in ≥80% of the affected areas at six months. Tissue cytokines were assessed at zero and three months.Results:
At six months, treatment success was achieved by 45% of patients, similarly in both groups. Tissue cytokine expression correlated well with clinical response.Conclusion:
Phototoxic regimen of topical PUVA deserves a place among therapeutic tools used in management of alopecia areata especially in more extensive conditions where intralesional corticosteroids would not be suitable. Trial registration https//clinicaltrials.gov/ct2/show/record/NCT01559584.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Terapia Ultravioleta
/
Alopecia em Áreas
Tipo de estudo:
Clinical_trials
Limite:
Adolescent
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Adult
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Child
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
J Dermatolog Treat
Assunto da revista:
DERMATOLOGIA
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Egito