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Discovery of naldemedine: A potent and orally available opioid receptor antagonist for treatment of opioid-induced adverse effects.
Inagaki, Masanao; Kume, Masaharu; Tamura, Yoshinori; Hara, Shinichiro; Goto, Yoshihisa; Haga, Nobuhiro; Hasegawa, Tsuyoshi; Nakamura, Takashi; Koike, Katsumi; Oonishi, Shuuichi; Kanemasa, Toshiyuki; Kai, Hiroyuki.
Afiliação
  • Inagaki M; Medicinal Chemistry Research Laboratory, Shionogi Co., Ltd., 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan. Electronic address: masanao.inagaki@shionogi.co.jp.
  • Kume M; Medicinal Chemistry Research Laboratory, Shionogi Co., Ltd., 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan.
  • Tamura Y; Medicinal Chemistry Research Laboratory, Shionogi Co., Ltd., 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan.
  • Hara S; Medicinal Chemistry Research Laboratory, Shionogi Co., Ltd., 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan.
  • Goto Y; Production Technology Department, Shionogi Co. & Ltd., 2-1-3 Kuise Terajima, Amagasaki, Hyogo 660-0813, Japan.
  • Haga N; Medicinal Chemistry Research Laboratory, Shionogi Co., Ltd., 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan.
  • Hasegawa T; Medicinal Chemistry Research Laboratory, Shionogi Co., Ltd., 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan.
  • Nakamura T; Shionogi TechnoAdvance Research Co., Ltd., 1405 Koga-cho Gotanda, Koga, Shiga 520-3423, Japan.
  • Koike K; Drug Discovery & Disease Research Laboratory, Shionogi & Co., Ltd, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan.
  • Oonishi S; Research Laboratory for Development, Shionogi & Co., Ltd, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan.
  • Kanemasa T; Drug Discovery & Disease Research Laboratory, Shionogi & Co., Ltd, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan.
  • Kai H; Medicinal Chemistry Research Laboratory, Shionogi Co., Ltd., 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan.
Bioorg Med Chem Lett ; 29(1): 73-77, 2019 01 01.
Article em En | MEDLINE | ID: mdl-30446313
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores Opioides delta / Receptores Opioides mu / Descoberta de Drogas / Analgésicos Opioides / Naltrexona Limite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores Opioides delta / Receptores Opioides mu / Descoberta de Drogas / Analgésicos Opioides / Naltrexona Limite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2019 Tipo de documento: Article