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Identification of Selective Acyl Sulfonamide-Cycloalkylether Inhibitors of the Voltage-Gated Sodium Channel (NaV) 1.7 with Potent Analgesic Activity.
Sun, Shaoyi; Jia, Qi; Zenova, Alla Y; Wilson, Michael S; Chowdhury, Sultan; Focken, Thilo; Li, Jun; Decker, Shannon; Grimwood, Michael E; Andrez, Jean-Christophe; Hemeon, Ivan; Sheng, Tao; Chen, Chien-An; White, Andy; Hackos, David H; Deng, Lunbin; Bankar, Girish; Khakh, Kuldip; Chang, Elaine; Kwan, Rainbow; Lin, Sophia; Nelkenbrecher, Karen; Sellers, Benjamin D; DiPasquale, Antonio G; Chang, Jae; Pang, Jodie; Sojo, Luis; Lindgren, Andrea; Waldbrook, Matthew; Xie, Zhiwei; Young, Clint; Johnson, James P; Robinette, C Lee; Cohen, Charles J; Safina, Brian S; Sutherlin, Daniel P; Ortwine, Daniel F; Dehnhardt, Christoph M.
Afiliação
  • Sun S; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.
  • Jia Q; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.
  • Zenova AY; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.
  • Wilson MS; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.
  • Chowdhury S; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.
  • Focken T; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.
  • Li J; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080-4990 , United States.
  • Decker S; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.
  • Grimwood ME; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.
  • Andrez JC; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.
  • Hemeon I; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.
  • Sheng T; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.
  • Chen CA; ChemPartner , Building No. 5, 998 Halei Road, Zhangjiang Hi-Tech Park, Pudong New Area , Shanghai 201203 , P. R. China.
  • White A; ChemPartner , Building No. 5, 998 Halei Road, Zhangjiang Hi-Tech Park, Pudong New Area , Shanghai 201203 , P. R. China.
  • Hackos DH; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080-4990 , United States.
  • Deng L; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080-4990 , United States.
  • Bankar G; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.
  • Khakh K; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.
  • Chang E; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.
  • Kwan R; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.
  • Lin S; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.
  • Nelkenbrecher K; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.
  • Sellers BD; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080-4990 , United States.
  • DiPasquale AG; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080-4990 , United States.
  • Chang J; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080-4990 , United States.
  • Pang J; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080-4990 , United States.
  • Sojo L; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.
  • Lindgren A; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.
  • Waldbrook M; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.
  • Xie Z; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.
  • Young C; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.
  • Johnson JP; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.
  • Robinette CL; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.
  • Cohen CJ; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.
  • Safina BS; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080-4990 , United States.
  • Sutherlin DP; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080-4990 , United States.
  • Ortwine DF; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080-4990 , United States.
  • Dehnhardt CM; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.
J Med Chem ; 62(2): 908-927, 2019 01 24.
Article em En | MEDLINE | ID: mdl-30499663
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sulfonamidas / Canal de Sódio Disparado por Voltagem NAV1.7 / Bloqueadores do Canal de Sódio Disparado por Voltagem / Analgésicos Tipo de estudo: Diagnostic_studies Limite: Animals / Humans / Male Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Canadá
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sulfonamidas / Canal de Sódio Disparado por Voltagem NAV1.7 / Bloqueadores do Canal de Sódio Disparado por Voltagem / Analgésicos Tipo de estudo: Diagnostic_studies Limite: Animals / Humans / Male Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Canadá