Electron injection from mitochondrial transcription factor A to DNA associated with thymine dimer photo repair.
Bioorg Med Chem
; 27(2): 278-284, 2019 01 15.
Article
em En
| MEDLINE
| ID: mdl-30552005
ABSTRACT
Electron transfer through π-stacked arrays of double-stranded DNA contributes to the redox chemistry of bases, including guanine oxidation and thymine-thymine dimer repair by photolyase. 5-Bromouracil is an attractive photoreactive thymine analogue that can be used to investigate electron transfer in DNA, and is a useful probe for protein-DNA interaction analysis. In the present study using BrU we found that UV irradiation facilitated electron injection from mitochondrial transcription factor A into DNA. We also observed that this electron injection could lead to repair of a thymine-thymine dimer.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dímeros de Pirimidina
/
Fatores de Transcrição
/
DNA
/
Proteínas Mitocondriais
/
Proteínas de Ligação a DNA
/
Reparo do DNA
/
Elétrons
Tipo de estudo:
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Japão