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Viral nanoparticles can elude protein barriers: exploiting rather than imitating nature.
Berardi, Alberto; Baldelli Bombelli, Francesca; Thuenemann, Eva C; Lomonossoff, George P.
Afiliação
  • Berardi A; Department of Pharmaceutical Sciences and Pharmaceutics, Faculty of Pharmacy, Applied Science Private University, Amman 11931, Jordan. a_berardi@asu.edu.jo.
Nanoscale ; 11(5): 2306-2316, 2019 Jan 31.
Article em En | MEDLINE | ID: mdl-30662985
Protein-corona formation in body fluids and/or entrapment of nanoparticles in protein matrices (e.g. food and mucus) can hinder the delivery of nanoparticles, irrespective of the route of administration. Here we demonstrate that certain viral nanoparticles (VNPs) can evade the adhesion of a broad panel of macromolecules from several biological milieus. We also show that the permeability of VNPs through mucin gels is far superior to that of synthetic nanoparticles. The non-sticky nature of VNPs implies that they will be able to readily cross most non-specific protein and glycoprotein barriers encountered, ubiquitously, upon administration through mucosal, and non-mucosal routes.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus / Proteínas / Nanopartículas / Coroa de Proteína Limite: Animals / Humans Idioma: En Revista: Nanoscale Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Jordânia

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus / Proteínas / Nanopartículas / Coroa de Proteína Limite: Animals / Humans Idioma: En Revista: Nanoscale Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Jordânia