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Application of hepatic cytochrome b5/P450 reductase null (HBRN) mice to study the role of cytochrome b5 in the cytochrome P450-mediated bioactivation of the anticancer drug ellipticine.
Reed, Lindsay; Indra, Radek; Mrizova, Iveta; Moserova, Michaela; Schmeiser, Heinz H; Wolf, C Roland; Henderson, Colin J; Stiborova, Marie; Phillips, David H; Arlt, Volker M.
Afiliação
  • Reed L; Department of Analytical, Environmental and Forensic Sciences, MRC-PHE Centre for Environment and Health, King's College London, London, United Kingdom.
  • Indra R; Department of Biochemistry, Faculty of Science, Charles University, Prague, Czech Republic.
  • Mrizova I; Department of Biochemistry, Faculty of Science, Charles University, Prague, Czech Republic.
  • Moserova M; Department of Biochemistry, Faculty of Science, Charles University, Prague, Czech Republic.
  • Schmeiser HH; Division of Radiopharmaceutical Chemistry, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Wolf CR; Division of Cancer Research, Jacqui Wood Cancer Centre, School of Medicine, University of Dundee, Ninewells Hospital, Dundee, United Kingdom.
  • Henderson CJ; Division of Cancer Research, Jacqui Wood Cancer Centre, School of Medicine, University of Dundee, Ninewells Hospital, Dundee, United Kingdom.
  • Stiborova M; Department of Biochemistry, Faculty of Science, Charles University, Prague, Czech Republic.
  • Phillips DH; Department of Analytical, Environmental and Forensic Sciences, MRC-PHE Centre for Environment and Health, King's College London, London, United Kingdom.
  • Arlt VM; Department of Analytical, Environmental and Forensic Sciences, MRC-PHE Centre for Environment and Health, King's College London, London, United Kingdom. Electronic address: volker.arlt@kcl.ac.uk.
Toxicol Appl Pharmacol ; 366: 64-74, 2019 03 01.
Article em En | MEDLINE | ID: mdl-30685480
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Citocromos b5 / Hepatócitos / Citocromo-B(5) Redutase / Elipticinas / Fígado / Antineoplásicos Limite: Animals Idioma: En Revista: Toxicol Appl Pharmacol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Citocromos b5 / Hepatócitos / Citocromo-B(5) Redutase / Elipticinas / Fígado / Antineoplásicos Limite: Animals Idioma: En Revista: Toxicol Appl Pharmacol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Reino Unido