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Discovery of Branebrutinib (BMS-986195): A Strategy for Identifying a Highly Potent and Selective Covalent Inhibitor Providing Rapid in Vivo Inactivation of Bruton's Tyrosine Kinase (BTK).
Watterson, Scott H; Liu, Qingjie; Beaudoin Bertrand, Myra; Batt, Douglas G; Li, Ling; Pattoli, Mark A; Skala, Stacey; Cheng, Lihong; Obermeier, Mary T; Moore, Robin; Yang, Zheng; Vickery, Rodney; Elzinga, Paul A; Discenza, Lorell; D'Arienzo, Celia; Gillooly, Kathleen M; Taylor, Tracy L; Pulicicchio, Claudine; Zhang, Yifan; Heimrich, Elizabeth; McIntyre, Kim W; Ruan, Qian; Westhouse, Richard A; Catlett, Ian M; Zheng, Naiyu; Chaudhry, Charu; Dai, Jun; Galella, Michael A; Tebben, Andrew J; Pokross, Matt; Li, Jianqing; Zhao, Rulin; Smith, Daniel; Rampulla, Richard; Allentoff, Alban; Wallace, Michael A; Mathur, Arvind; Salter-Cid, Luisa; Macor, John E; Carter, Percy H; Fura, Aberra; Burke, James R; Tino, Joseph A.
Afiliação
  • Watterson SH; Bristol-Myers Squibb Research and Development , P.O. Box 4000, Princeton , New Jersey 08543 , United States.
  • Liu Q; Bristol-Myers Squibb Research and Development , P.O. Box 4000, Princeton , New Jersey 08543 , United States.
  • Beaudoin Bertrand M; Bristol-Myers Squibb Research and Development , P.O. Box 4000, Princeton , New Jersey 08543 , United States.
  • Batt DG; Bristol-Myers Squibb Research and Development , P.O. Box 4000, Princeton , New Jersey 08543 , United States.
  • Li L; Bristol-Myers Squibb Research and Development , P.O. Box 4000, Princeton , New Jersey 08543 , United States.
  • Pattoli MA; Bristol-Myers Squibb Research and Development , P.O. Box 4000, Princeton , New Jersey 08543 , United States.
  • Skala S; Bristol-Myers Squibb Research and Development , P.O. Box 4000, Princeton , New Jersey 08543 , United States.
  • Cheng L; Bristol-Myers Squibb Research and Development , P.O. Box 4000, Princeton , New Jersey 08543 , United States.
  • Obermeier MT; Bristol-Myers Squibb Research and Development , P.O. Box 4000, Princeton , New Jersey 08543 , United States.
  • Moore R; Bristol-Myers Squibb Research and Development , P.O. Box 4000, Princeton , New Jersey 08543 , United States.
  • Yang Z; Bristol-Myers Squibb Research and Development , P.O. Box 4000, Princeton , New Jersey 08543 , United States.
  • Vickery R; Bristol-Myers Squibb Research and Development , P.O. Box 4000, Princeton , New Jersey 08543 , United States.
  • Elzinga PA; Bristol-Myers Squibb Research and Development , P.O. Box 4000, Princeton , New Jersey 08543 , United States.
  • Discenza L; Bristol-Myers Squibb Research and Development , P.O. Box 4000, Princeton , New Jersey 08543 , United States.
  • D'Arienzo C; Bristol-Myers Squibb Research and Development , P.O. Box 4000, Princeton , New Jersey 08543 , United States.
  • Gillooly KM; Bristol-Myers Squibb Research and Development , P.O. Box 4000, Princeton , New Jersey 08543 , United States.
  • Taylor TL; Bristol-Myers Squibb Research and Development , P.O. Box 4000, Princeton , New Jersey 08543 , United States.
  • Pulicicchio C; Bristol-Myers Squibb Research and Development , P.O. Box 4000, Princeton , New Jersey 08543 , United States.
  • Zhang Y; Bristol-Myers Squibb Research and Development , P.O. Box 4000, Princeton , New Jersey 08543 , United States.
  • Heimrich E; Bristol-Myers Squibb Research and Development , P.O. Box 4000, Princeton , New Jersey 08543 , United States.
  • McIntyre KW; Bristol-Myers Squibb Research and Development , P.O. Box 4000, Princeton , New Jersey 08543 , United States.
  • Ruan Q; Bristol-Myers Squibb Research and Development , P.O. Box 4000, Princeton , New Jersey 08543 , United States.
  • Westhouse RA; Bristol-Myers Squibb Research and Development , P.O. Box 4000, Princeton , New Jersey 08543 , United States.
  • Catlett IM; Bristol-Myers Squibb Research and Development , P.O. Box 4000, Princeton , New Jersey 08543 , United States.
  • Zheng N; Bristol-Myers Squibb Research and Development , P.O. Box 4000, Princeton , New Jersey 08543 , United States.
  • Chaudhry C; Bristol-Myers Squibb Research and Development , P.O. Box 4000, Princeton , New Jersey 08543 , United States.
  • Dai J; Bristol-Myers Squibb Research and Development , P.O. Box 4000, Princeton , New Jersey 08543 , United States.
  • Galella MA; Bristol-Myers Squibb Research and Development , P.O. Box 4000, Princeton , New Jersey 08543 , United States.
  • Tebben AJ; Bristol-Myers Squibb Research and Development , P.O. Box 4000, Princeton , New Jersey 08543 , United States.
  • Pokross M; Bristol-Myers Squibb Research and Development , P.O. Box 4000, Princeton , New Jersey 08543 , United States.
  • Li J; Bristol-Myers Squibb Research and Development , P.O. Box 4000, Princeton , New Jersey 08543 , United States.
  • Zhao R; Bristol-Myers Squibb Research and Development , P.O. Box 4000, Princeton , New Jersey 08543 , United States.
  • Smith D; Bristol-Myers Squibb Research and Development , P.O. Box 4000, Princeton , New Jersey 08543 , United States.
  • Rampulla R; Bristol-Myers Squibb Research and Development , P.O. Box 4000, Princeton , New Jersey 08543 , United States.
  • Allentoff A; Bristol-Myers Squibb Research and Development , P.O. Box 4000, Princeton , New Jersey 08543 , United States.
  • Wallace MA; Bristol-Myers Squibb Research and Development , P.O. Box 4000, Princeton , New Jersey 08543 , United States.
  • Mathur A; Bristol-Myers Squibb Research and Development , P.O. Box 4000, Princeton , New Jersey 08543 , United States.
  • Salter-Cid L; Bristol-Myers Squibb Research and Development , P.O. Box 4000, Princeton , New Jersey 08543 , United States.
  • Macor JE; Bristol-Myers Squibb Research and Development , P.O. Box 4000, Princeton , New Jersey 08543 , United States.
  • Carter PH; Bristol-Myers Squibb Research and Development , P.O. Box 4000, Princeton , New Jersey 08543 , United States.
  • Fura A; Bristol-Myers Squibb Research and Development , P.O. Box 4000, Princeton , New Jersey 08543 , United States.
  • Burke JR; Bristol-Myers Squibb Research and Development , P.O. Box 4000, Princeton , New Jersey 08543 , United States.
  • Tino JA; Bristol-Myers Squibb Research and Development , P.O. Box 4000, Princeton , New Jersey 08543 , United States.
J Med Chem ; 62(7): 3228-3250, 2019 04 11.
Article em En | MEDLINE | ID: mdl-30893553
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piperidinas / Inibidores de Proteínas Quinases / Descoberta de Drogas / Tirosina Quinase da Agamaglobulinemia / Indóis Limite: Animals / Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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XML
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piperidinas / Inibidores de Proteínas Quinases / Descoberta de Drogas / Tirosina Quinase da Agamaglobulinemia / Indóis Limite: Animals / Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos