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Stabilization of amyloidogenic immunoglobulin light chains by small molecules.
Morgan, Gareth J; Yan, Nicholas L; Mortenson, David E; Rennella, Enrico; Blundon, Joshua M; Gwin, Ryan M; Lin, Chung-Yon; Stanfield, Robyn L; Brown, Steven J; Rosen, Hugh; Spicer, Timothy P; Fernandez-Vega, Virneliz; Merlini, Giampaolo; Kay, Lewis E; Wilson, Ian A; Kelly, Jeffery W.
Afiliação
  • Morgan GJ; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037; gjmorgan@bu.edu jkelly@scripps.edu.
  • Yan NL; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037.
  • Mortenson DE; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037.
  • Rennella E; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037.
  • Blundon JM; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037.
  • Gwin RM; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037.
  • Lin CY; Department of Molecular Genetics, The University of Toronto, Toronto, ON M5S1A8, Canada.
  • Stanfield RL; Department of Biochemistry, The University of Toronto, Toronto, ON M5S1A8, Canada.
  • Brown SJ; Department of Chemistry, The University of Toronto, Toronto, ON M5S1A8, Canada.
  • Rosen H; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037.
  • Spicer TP; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037.
  • Fernandez-Vega V; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037.
  • Merlini G; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037.
  • Kay LE; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037.
  • Wilson IA; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037.
  • Kelly JW; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037.
Proc Natl Acad Sci U S A ; 116(17): 8360-8369, 2019 04 23.
Article em En | MEDLINE | ID: mdl-30971495
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cadeias Leves de Imunoglobulina / Estabilidade Proteica / Amiloide Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cadeias Leves de Imunoglobulina / Estabilidade Proteica / Amiloide Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2019 Tipo de documento: Article