AAV2/DJ-mediated alpha-synuclein overexpression in the rat substantia nigra as early stage model of Parkinson's disease.

von Hövel, Friederike Freiin; Rumpel, Regina; Ratzka, Andreas; Schreiner, Dietmar; Grothe, Claudia

von Hövel, Friederike Freiin; Rumpel, Regina; Ratzka, Andreas; Schreiner, Dietmar; Grothe, Claudia.

Afiliação

von Hövel FF; Institute of Neuroanatomy and Cell Biology, Hannover Medical School, OE 4140, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
Rumpel R; Center for Systems Neuroscience (ZSN), Hannover Medical School, Institute of Neuroanatomy and Cell Biology, Carl-Neuberg-Strasse 1, 30625, Hannover, Germany.
Ratzka A; Institute for Laboratory Animal Science and Central Animal Facility, Hannover Medical School, OE 8600, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
Schreiner D; Institute of Neuroanatomy and Cell Biology, Hannover Medical School, OE 4140, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
Grothe C; Institute of Neuroanatomy and Cell Biology, Hannover Medical School, OE 4140, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.

Cell Tissue Res ; 378(1): 1-14, 2019 Oct.

Article em En | MEDLINE | ID: mdl-30989398

Assuntos

Modelos Animais de Doenças; Doença de Parkinson/metabolismo; Parte Compacta da Substância Negra/metabolismo; alfa-Sinucleína/metabolismo; Animais; Dependovirus; Feminino; Vetores Genéticos; Parvovirinae/genética; Ratos; Ratos Sprague-Dawley

Palavras-chave

AAV2/DJ; Alpha-synuclein; E46K; Parkinson's disease; Rat model

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Modelos Animais de Doenças / Alfa-Sinucleína / Parte Compacta da Substância Negra Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Cell Tissue Res Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Alemanha

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