Effect of maternal baboon (Papio sp.) dietary mismatch in pregnancy and lactation on post-natal offspring early life phenotype.
J Med Primatol
; 48(4): 226-235, 2019 08.
Article
em En
| MEDLINE
| ID: mdl-31025367
ABSTRACT
BACKGROUND:
Non-human primate models of developmental programing by maternal mismatch between pregnancy and lactation diets are needed for translation to human programing outcomes. We present baboon offspring morphometry from birth to 3 years, and blood cortisol and adrenocorticotropin (ACTH) from 2 to 24 months.METHODS:
Control mothers ate chow; mismatch mothers ate 30% less than controls during pregnancy and high-fat high-energy diet through lactation.RESULTS:
Mismatch mothers lost weight during pregnancy. At birth, there were trends toward lower weight in mismatch offspring of both sexes (P = 0.06). From 0-3 years, catch-up growth occurred. Mismatch offspring male and female body weight increased faster than controls (P < 0.001). Mismatch female offspring showed greater increase in BMI (P < 0.001) and abdominal circumference (P = 0.008) vs controls. ACTH and cortisol slopes from 2 to 24 months of age were similar between groups in both sexes. Cortisol and ACTH increased after weaning in all groups.CONCLUSIONS:
Mismatch produces sexually dimorphic post-natal growth phenotypes.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Papio
/
Peso Corporal
/
Lactação
/
Gravidez
/
Dieta Hiperlipídica
Limite:
Animals
Idioma:
En
Revista:
J Med Primatol
Ano de publicação:
2019
Tipo de documento:
Article