Hemostatic Abnormalities in Dementia: A Systematic Review and Meta-Analysis.
Semin Thromb Hemost
; 45(5): 514-522, 2019 Jul.
Article
em En
| MEDLINE
| ID: mdl-31096308
ABSTRACT
Alzheimer's disease (AD) is considered the most frequent cause of dementia. It is known that vascular risk factors play an important role in the development and progression of this condition. Alterations in vascular walls represent documented findings in patients with AD and other dementias affecting elderly people. The authors performed a systematic review and meta-analysis, aiming to synthesize observational studies that evaluated how the hemostatic system may contribute to cognitive decline in the elderly, using papers published until April 2018 and as indexed in Medline (PubMed), Scopus, Web of Science, ScienceDirect, Lilacs, Cinahl, PsycINFO, Cochrane Central Register of Controlled Trials, and Cochrane Database of Systematic Reviews. Among 5,278 studies identified, 32 were included in the final synthesis, and these included 485 patients with mild cognitive impairment, 568 with vascular dementia (VD), 1,781 with AD, and 2,855 participants without dementia. AD patients had increased plasma von Willebrand factor (VWF) (standardized mean difference [SMD] 2.53; 95% confidence interval [CI] 0.10-4.95), D-dimer (SMD 0.50; 95% CI 0.35-0.66), plasminogen activator inhibitor-1 (SMD 3.34; 95% CI 1.01-5.67), thrombomodulin (SMD 1.08; 95% CI 0.53-1.62), and homocysteine levels (SMD 0.65; 95% CI 0.15-1.15). In contrast, the VD group showed increased fibrinogen levels (SMD 0.77; 95% CI 0.13-1.41), activated factor VII (SMD 0.36; 95% CI 0.05-0.67), factor VIII (SMD 0.57; 95% CI 0.22-0.91), VWF (SMD 2.34; 95% CI 0.38-4.29), D-dimer (SMD 1.14; 95% CI 0.51-1.78), and homocysteine (SMD 2.17; 95% CI 1.67-2.68). AD showed an elevation in some markers of endothelial dysfunction, whereas VD presented mostly an involvement of coagulation cascade components.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hemostáticos
/
Demência
/
Doença de Alzheimer
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Revista:
Semin Thromb Hemost
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Brasil