Population-level adult mortality following the expansion of antiretroviral therapy in Rakai, Uganda.
Popul Stud (Camb)
; 74(1): 93-102, 2020 03.
Article
em En
| MEDLINE
| ID: mdl-31117928
ABSTRACT
There are limited data on the impact of antiretroviral therapy (ART) on population-level adult mortality in sub-Saharan Africa. We analysed data for 2000-14 from the Rakai Community Cohort Study (RCCS) in Uganda, where free ART was scaled up after 2004. Using non-parametric and parametric (Weibull) survival analysis, we estimated trends in average person-years lived between exact ages 15 and 50, per capita life-years lost to HIV, and the mortality hazards of people living with HIV (PLHIV). Between 2000 and 2014, average adult life-years lived before age 50 increased significantly, from 26.4 to 33.5â
years for all women and from 28.6 to 33.8â
years for all men. As of 2014, life-years lost to HIV had declined significantly, to 1.3â
years among women and 0.4â
years among men. Following the roll-out of ART, mortality reductions among PLHIV were initially larger in women than men, but this is no longer the case.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções por HIV
/
Mortalidade
/
Antirretrovirais
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Africa
Idioma:
En
Revista:
Popul Stud (Camb)
Ano de publicação:
2020
Tipo de documento:
Article