Peroxisome proliferator-activated receptor-Î³ coactivator 1&#945;-mediated pathway as a possible therapeutic target in endometriosis.

Kataoka, Hisashi; Mori, Taisuke; Okimura, Hiroyuki; Matsushima, Hiroshi; Ito, Fumitake; Koshiba, Akemi; Tanaka, Yukiko; Akiyama, Kanoko; Maeda, Eiko; Sugahara, Takuya; Tarumi, Yosuke; Kusuki, Izumi; Khan, Khaleque N; Kitawaki, Jo

Peroxisome proliferator-activated receptor-Î³ coactivator 1α-mediated pathway as a possible therapeutic target in endometriosis.

Kataoka, Hisashi; Mori, Taisuke; Okimura, Hiroyuki; Matsushima, Hiroshi; Ito, Fumitake; Koshiba, Akemi; Tanaka, Yukiko; Akiyama, Kanoko; Maeda, Eiko; Sugahara, Takuya; Tarumi, Yosuke; Kusuki, Izumi; Khan, Khaleque N; Kitawaki, Jo.

Afiliação

Kataoka H; Department of Obstetrics and Gynecology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, Japan.
Mori T; Department of Obstetrics and Gynecology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, Japan.
Okimura H; Department of Obstetrics and Gynecology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, Japan.
Matsushima H; Department of Obstetrics and Gynecology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, Japan.
Ito F; Department of Obstetrics and Gynecology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, Japan.
Koshiba A; Department of Obstetrics and Gynecology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, Japan.
Tanaka Y; Department of Obstetrics and Gynecology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, Japan.
Akiyama K; Department of Obstetrics and Gynecology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, Japan.
Maeda E; Department of Obstetrics and Gynecology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, Japan.
Sugahara T; Department of Obstetrics and Gynecology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, Japan.
Tarumi Y; Department of Obstetrics and Gynecology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, Japan.
Kusuki I; Department of Obstetrics and Gynecology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, Japan.
Khan KN; Department of Obstetrics and Gynecology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, Japan.
Kitawaki J; Department of Obstetrics and Gynecology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, Japan.

Hum Reprod ; 34(6): 1019-1029, 2019 06 04.

Article em En | MEDLINE | ID: mdl-31119261

Assuntos

Endometriose/genética; Endométrio/patologia; Coativador 1-alfa do Receptor gama Ativado por Proliferador de Peroxissomo/metabolismo; Transdução de Sinais/genética; Adulto; Apoptose/efeitos dos fármacos; Apoptose/genética; Aromatase/genética; Benzoatos/farmacologia; Benzoatos/uso terapêutico; Compostos de Bifenilo/farmacologia; Compostos de Bifenilo/uso terapêutico; Estudos de Casos e Controles; Proliferação de Células/efeitos dos fármacos; Proliferação de Células/genética; Células Cultivadas; Regulação para Baixo/efeitos dos fármacos; Endometriose/tratamento farmacológico; Endometriose/patologia; Endométrio/citologia; Estrogênios/metabolismo; Feminino; Técnicas de Silenciamento de Genes; Humanos; Pessoa de Meia-Idade; Coativador 1-alfa do Receptor gama Ativado por Proliferador de Peroxissomo/antagonistas & inibidores; Coativador 1-alfa do Receptor gama Ativado por Proliferador de Peroxissomo/genética; Cultura Primária de Células; Regiões Promotoras Genéticas/genética; RNA Interferente Pequeno/metabolismo; Receptor X Retinoide alfa/metabolismo; Transdução de Sinais/efeitos dos fármacos; Células Estromais; Transcrição Gênica/efeitos dos fármacos; Adulto Jovem

Palavras-chave

PGC-1α; apoptosis; endometriosis; estrogen dependence; inflammation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Endometriose / Endométrio / Coativador 1-alfa do Receptor gama Ativado por Proliferador de Peroxissomo Tipo de estudo: Observational_studies / Risk_factors_studies Idioma: En Revista: Hum Reprod Assunto da revista: MEDICINA REPRODUTIVA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Japão

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