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One-year Mortality Outcomes From the Advancing Cryptococcal Meningitis Treatment for Africa Trial of Cryptococcal Meningitis Treatment in Malawi.
Kanyama, Cecilia; Molloy, Síle F; Chan, Adrienne K; Lupiya, Duncan; Chawinga, Chimwemwe; Adams, Jack; Bright, Philip; Lalloo, David G; Heyderman, Robert S; Lortholary, Olivier; Jaffar, Shabbar; Loyse, Angela; van Oosterhout, Joep J; Hosseinipour, Mina C; Harrison, Thomas S.
Afiliação
  • Kanyama C; University of North Carolina Project-Malawi, Kamuzu Central Hospital, Lilongwe.
  • Molloy SF; Centre for Global Health, Institute for Infection and Immunity, St George's University of London, United Kingdom.
  • Chan AK; Dignitas International, Zomba Central Hospital, Malawi.
  • Lupiya D; Division of Infectious Diseases, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Canada.
  • Chawinga C; Dignitas International, Zomba Central Hospital, Malawi.
  • Adams J; University of North Carolina Project-Malawi, Kamuzu Central Hospital, Lilongwe.
  • Bright P; Centre for Global Health, Institute for Infection and Immunity, St George's University of London, United Kingdom.
  • Lalloo DG; Dignitas International, Zomba Central Hospital, Malawi.
  • Heyderman RS; Clinical Immunology Department, North Bristol National Health Service Trust, United Kingdom.
  • Lortholary O; Liverpool School of Tropical Medicine, United Kingdom.
  • Jaffar S; Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre.
  • Loyse A; Department of Medicine, College of Medicine, University of Malawi, Blantyre.
  • van Oosterhout JJ; University College London, United Kingdom.
  • Hosseinipour MC; Institut Pasteur, Molecular Mycology Unit, National Reference Center for Invasive Mycoses & Antifungals, Centre National de la Recherche Scientifique, Paris.
  • Harrison TS; Paris Descartes University, Necker Pasteur Center for Infectious Diseases and Tropical Medicine, Institut Hospitalo-Universitaire Imagine, Assistance Publique - Hôpitaux de Paris, France.
Clin Infect Dis ; 70(3): 521-524, 2020 01 16.
Article em En | MEDLINE | ID: mdl-31155650
In Malawi, 236 participants from the Advancing Cryptococcal Meningitis Treatment for Africa trial were followed for 12 months. The trial outcomes reported at 10 weeks were sustained to 1 year. One-week amphotericin B plus flucytosine was associated with the lowest 1 year mortality (27.5% [95% confidence interval, 16.3 to 44.1]).
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Meningite Criptocócica Limite: Humans País/Região como assunto: Africa Idioma: En Revista: Clin Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Meningite Criptocócica Limite: Humans País/Região como assunto: Africa Idioma: En Revista: Clin Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2020 Tipo de documento: Article