Structures of vertebrate Patched and Smoothened reveal intimate links between cholesterol and Hedgehog signalling.

Kowatsch, Christiane; Woolley, Rachel E; Kinnebrew, Maia; Rohatgi, Rajat; Siebold, Christian

Kowatsch, Christiane; Woolley, Rachel E; Kinnebrew, Maia; Rohatgi, Rajat; Siebold, Christian.

Afiliação

Kowatsch C; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Woolley RE; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Kinnebrew M; Departments of Biochemistry and Medicine, Stanford University School of Medicine, Stanford, CA, United States.
Rohatgi R; Departments of Biochemistry and Medicine, Stanford University School of Medicine, Stanford, CA, United States. Electronic address: rrohatgi@stanford.edu.
Siebold C; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK. Electronic address: christian@strubi.ox.ac.uk.

Curr Opin Struct Biol ; 57: 204-214, 2019 08.

Article em En | MEDLINE | ID: mdl-31247512

Assuntos

Colesterol/metabolismo; Proteínas Hedgehog/metabolismo; Receptores Patched/química; Receptores Patched/metabolismo; Transdução de Sinais; Receptor Smoothened/química; Receptor Smoothened/metabolismo; Animais; Humanos; Coluna Vertebral

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Colesterol / Proteínas Hedgehog / Receptores Patched / Receptor Smoothened Limite: Animals / Humans Idioma: En Revista: Curr Opin Struct Biol Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Reino Unido

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