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Isorhamnetin ameliorates inflammatory responses and articular cartilage damage in the rats of monosodium iodoacetate-induced osteoarthritis.
Tsai, Sen-Wei; Lin, Chi-Chien; Lin, Shih-Chao; Wang, Shun-Ping; Yang, Deng-Ho.
Afiliação
  • Tsai SW; Department of Physical Medicine and Rehabilitation, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation , Taichung , Republic of China.
  • Lin CC; Department of Physical Medicine and Rehabilitation, School of Medicine, Tzu Chi University , Hualien , Republic of China.
  • Lin SC; Institute of Biomedical Science, National Chung-Hsing University , Taichung , Republic of China.
  • Wang SP; Department of Medical Research, China Medical University Hospital , Taichung , Republic of China.
  • Yang DH; National Center for Biodefense and Infectious Diseases, School of Systems Biology, George Mason University , Manassas , VA , USA.
Immunopharmacol Immunotoxicol ; 41(4): 504-512, 2019 Aug.
Article em En | MEDLINE | ID: mdl-31342791
Context: Osteoarthritis (OA) is a degenerative joint disease with damage to the articular cartilage. Active production of inflammatory cytokine/chemokine and matrix metalloproteinases may be found during the progression of OA. Isorhamnetin had the effects of anti-inflammatory, antioxidant, anti-ischemia, anti-atherosclerotic hepatoprotective and anticancer activities. Objective: Our study was focused on the effects of isorhamnetin treatment in OA. Materials and methods: We used monosodium iodoacetate (MIA)-induced OA rats to evaluate the effects of isorhamnetin related anti-inflammatory process. The rats in all groups were sacrificed on four weeks post-MIA injection. The measurements of knee joint swelling, histological analysis, serum inflammatory biomarkers and western blot were evaluated. Results: We found that isorhamnetin may reduce MIA-induced knee swelling by significantly reduction of articular cartilage damage.in rats. Suppression of pro-inflammatory cytokines production was found after isohamnetin treatment. Isorhamnetin inhibited the production of NO and PGE2, and the expression of iNOS and COX-2. The production of COMP, CTX-II and osteopontin (OPN) were also inhibited in MIA-induced OA rats. Discussion and conclusions: Isorhamnetin may modulate the inflammatory progression of OA in MIA-induced OA rats. The prevention of cartilage damage was found in OA after adequate isorhamnetin treatment. Isorhamnetin may serve as a potential agent for the management of OA.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteoartrite / Quercetina / Cartilagem Articular / Inflamação / Iodoacetatos / Anti-Inflamatórios Limite: Animals Idioma: En Revista: Immunopharmacol Immunotoxicol Assunto da revista: ALERGIA E IMUNOLOGIA / FARMACOLOGIA / TOXICOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteoartrite / Quercetina / Cartilagem Articular / Inflamação / Iodoacetatos / Anti-Inflamatórios Limite: Animals Idioma: En Revista: Immunopharmacol Immunotoxicol Assunto da revista: ALERGIA E IMUNOLOGIA / FARMACOLOGIA / TOXICOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China