Magnetic targeting of adoptively transferred tumour-specific nanoparticle-loaded CD8<sup>+</sup> T cells does not improve their tumour infiltration in a mouse model of cancer but promotes the retention of these cells in tumour-draining lymph nodes.

Sanz-Ortega, Laura; Portilla, Yadileiny; Pérez-Yagüe, Sonia; Barber, Domingo F

Magnetic targeting of adoptively transferred tumour-specific nanoparticle-loaded CD8⁺ T cells does not improve their tumour infiltration in a mouse model of cancer but promotes the retention of these cells in tumour-draining lymph nodes.

Sanz-Ortega, Laura; Portilla, Yadileiny; Pérez-Yagüe, Sonia; Barber, Domingo F.

Afiliação

Sanz-Ortega L; Department of Immunology and Oncology, and NanoBiomedicine Initiative, Centro Nacional de Biotecnología (CNB)-CSIC, Darwin 3, Cantoblanco, 28049, Madrid, Spain.
Portilla Y; Department of Immunology and Oncology, and NanoBiomedicine Initiative, Centro Nacional de Biotecnología (CNB)-CSIC, Darwin 3, Cantoblanco, 28049, Madrid, Spain.
Pérez-Yagüe S; Department of Immunology and Oncology, and NanoBiomedicine Initiative, Centro Nacional de Biotecnología (CNB)-CSIC, Darwin 3, Cantoblanco, 28049, Madrid, Spain.
Barber DF; Department of Immunology and Oncology, and NanoBiomedicine Initiative, Centro Nacional de Biotecnología (CNB)-CSIC, Darwin 3, Cantoblanco, 28049, Madrid, Spain. dfbarber@cnb.csic.es.

J Nanobiotechnology ; 17(1): 87, 2019 Aug 06.

Article em En | MEDLINE | ID: mdl-31387604

Assuntos

Transferência Adotiva; Linfócitos T CD8-Positivos/transplante; Linfonodos/patologia; Linfócitos do Interstício Tumoral/imunologia; Nanopartículas de Magnetita/química; Neoplasias Experimentais/terapia; Animais; Linfócitos T CD8-Positivos/imunologia; Linhagem Celular Tumoral; Permeabilidade da Membrana Celular; Proliferação de Células; Sobrevivência Celular; Feminino; Linfonodos/imunologia; Ativação Linfocitária; Linfócitos do Interstício Tumoral/patologia; Camundongos Endogâmicos C57BL; Transplante de Neoplasias; Neoplasias Experimentais/imunologia; Neoplasias Experimentais/patologia; Propilaminas/química; Silanos/química

Palavras-chave

Cancer immunotherapy; Cell-based therapy; Effector T cell; Magnetic nanoparticle; Magnetic retention

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos do Interstício Tumoral / Linfócitos T CD8-Positivos / Transferência Adotiva / Nanopartículas de Magnetita / Linfonodos / Neoplasias Experimentais Tipo de estudo: Guideline Limite: Animals Idioma: En Revista: J Nanobiotechnology Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Espanha

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