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Agreement between molecular subtyping and surrogate subtype classification: a contemporary population-based study of ER-positive/HER2-negative primary breast cancer.
Lundgren, Christine; Bendahl, Pär-Ola; Borg, Åke; Ehinger, Anna; Hegardt, Cecilia; Larsson, Christer; Loman, Niklas; Malmberg, Martin; Olofsson, Helena; Saal, Lao H; Sjöblom, Tobias; Lindman, Henrik; Klintman, Marie; Häkkinen, Jari; Vallon-Christersson, Johan; Fernö, Mårten; Rydén, Lisa; Ekholm, Maria.
Afiliação
  • Lundgren C; Department of Oncology, Jönköping, Region Jönköping County, and Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden. christine.lundgren@med.lu.se.
  • Bendahl PO; Department of Clinical Sciences Lund, Division of Oncology and Pathology, Lund University, Lund, Sweden. christine.lundgren@med.lu.se.
  • Borg Å; Department of Clinical Sciences Lund, Division of Oncology and Pathology, Lund University, Lund, Sweden.
  • Ehinger A; Department of Clinical Sciences Lund, Division of Oncology and Pathology, Lund University, Lund, Sweden.
  • Hegardt C; Department of Clinical Sciences Lund, Division of Oncology and Pathology, Lund University, Lund, Sweden.
  • Larsson C; Department of Clinical Sciences Lund, Division of Oncology and Pathology, Lund University, Lund, Sweden.
  • Loman N; Department of Laboratory Medicine Lund, Division of Translational Cancer Research, Lund University, Lund, Sweden.
  • Malmberg M; Department of Clinical Sciences Lund, Division of Oncology and Pathology, Lund University, Lund, Sweden.
  • Olofsson H; Department of Hematology, Oncology and Radiation Physics, Skåne University Hospital, Lund, Sweden.
  • Saal LH; Department of Clinical Sciences Lund, Division of Oncology and Pathology, Lund University, Lund, Sweden.
  • Sjöblom T; Department of Hematology, Oncology and Radiation Physics, Skåne University Hospital, Lund, Sweden.
  • Lindman H; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
  • Klintman M; Department of Clinical Sciences Lund, Division of Oncology and Pathology, Lund University, Lund, Sweden.
  • Häkkinen J; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
  • Vallon-Christersson J; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
  • Fernö M; Department of Clinical Sciences Lund, Division of Oncology and Pathology, Lund University, Lund, Sweden.
  • Rydén L; Department of Clinical Sciences Lund, Division of Oncology and Pathology, Lund University, Lund, Sweden.
  • Ekholm M; Department of Clinical Sciences Lund, Division of Oncology and Pathology, Lund University, Lund, Sweden.
Breast Cancer Res Treat ; 178(2): 459-467, 2019 Nov.
Article em En | MEDLINE | ID: mdl-31432367
ABSTRACT

PURPOSE:

Oestrogen receptor-positive (ER+) and human epidermal receptor 2-negative (HER2-) breast cancers are classified as Luminal A or B based on gene expression, but immunohistochemical markers are used for surrogate subtyping. The aims of this study were to examine the agreement between molecular subtyping (MS) and surrogate subtyping and to identify subgroups consisting mainly of Luminal A or B tumours.

METHODS:

The cohort consisted of 2063 patients diagnosed between 2013-2017, with primary ER+/HER2- breast cancer, analysed by RNA sequencing. Surrogate subtyping was performed according to three algorithms (St. Gallen 2013, Maisonneuve and our proposed Grade-based classification). Agreement (%) and kappa statistics (κ) were used as concordance measures and ROC analysis for luminal distinction. Ki67, progesterone receptor (PR) and histological grade (HG) were further investigated as surrogate markers.

RESULTS:

The agreement rates between the MS and St. Gallen 2013, Maisonneuve and Grade-based classifications were 62% (κ = 0.30), 66% (κ = 0.35) and 70% (κ = 0.41), respectively. PR did not contribute to distinguishing Luminal A from B tumours (auROC = 0.56). By classifying HG1-2 tumours as Luminal A-like and HG3 as Luminal B-like, agreement with MS was 80% (κ = 0.46). Moreover, by combining HG and Ki67 status, a large subgroup of patients (51% of the cohort) having > 90% Luminal A tumours could be identified.

CONCLUSIONS:

Agreement between MS and surrogate classifications was generally poor. However, a post hoc analysis showed that a combination of HG and Ki67 could identify patients very likely to have Luminal A tumours according to MS.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Biomarcadores Tumorais Tipo de estudo: Diagnostic_studies / Prognostic_studies / Screening_studies Limite: Female / Humans Idioma: En Revista: Breast Cancer Res Treat Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Suécia

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Biomarcadores Tumorais Tipo de estudo: Diagnostic_studies / Prognostic_studies / Screening_studies Limite: Female / Humans Idioma: En Revista: Breast Cancer Res Treat Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Suécia