Ultrasound mediated efficient synthesis of new 4-oxoquinazolin-3(4H)-yl)furan-2-carboxamides as potent tyrosinase inhibitors: Mechanistic approach through chemoinformatics and molecular docking studies.

Dige, Nilam C; Mahajan, Prasad G; Raza, Hussain; Hassan, Mubashir; Vanjare, Balasaheb D; Hong, Hansol; Hwan Lee, Ki; Latip, Jalifah; Seo, Sung-Yum

Dige, Nilam C; Mahajan, Prasad G; Raza, Hussain; Hassan, Mubashir; Vanjare, Balasaheb D; Hong, Hansol; Hwan Lee, Ki; Latip, Jalifah; Seo, Sung-Yum.

Afiliação

Dige NC; Department of Biological Sciences, Kongju National University, Gongju, Chungnam 32588, Republic of Korea.
Mahajan PG; Department of Chemistry, Kongju National University, Gongju, Chungnam 32588, Republic of Korea.
Raza H; Department of Biological Sciences, Kongju National University, Gongju, Chungnam 32588, Republic of Korea.
Hassan M; Institute of Molecular Biology and Biotechnology, The University of Lahore, Defence Road, Lahore 54590, Pakistan.
Vanjare BD; Department of Chemistry, Kongju National University, Gongju, Chungnam 32588, Republic of Korea.
Hong H; Department of Biological Sciences, Kongju National University, Gongju, Chungnam 32588, Republic of Korea.
Hwan Lee K; Department of Chemistry, Kongju National University, Gongju, Chungnam 32588, Republic of Korea.
Latip J; School of Chemical Sciences and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia (UKM), 43600 Bangi, Selangor, Malaysia. Electronic address: jalifah@ukm.edu.my.
Seo SY; Department of Biological Sciences, Kongju National University, Gongju, Chungnam 32588, Republic of Korea. Electronic address: dnalove@kongju.ac.kr.

Bioorg Chem ; 92: 103201, 2019 11.

Article em En | MEDLINE | ID: mdl-31445195

Assuntos

Inibidores Enzimáticos/síntese química; Monofenol Mono-Oxigenase/antagonistas & inibidores; Quinolonas/síntese química; Sequência de Aminoácidos; Sítios de Ligação; Quimioinformática; Simulação por Computador; Desenho de Fármacos; Inibidores Enzimáticos/metabolismo; Furanos/química; Cinética; Simulação de Acoplamento Molecular; Estrutura Molecular; Ligação Proteica; Pironas/metabolismo; Relação Estrutura-Atividade; Ondas Ultrassônicas

Palavras-chave

Drug score; Lipinski's rule; Molecular docking; Oxoquinazolin-3(4H)-yl)furan-2-carboxamides; Tyrosinase; Ultrasound sonication

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Monofenol Mono-Oxigenase / Quinolonas / Inibidores Enzimáticos Tipo de estudo: Prognostic_studies Idioma: En Revista: Bioorg Chem Ano de publicação: 2019 Tipo de documento: Article

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