Lean body mass accretion is elevated in response to dietary vitamin D: A dose-response study in female weanling rats.
Nutr Res
; 68: 92-100, 2019 08.
Article
em En
| MEDLINE
| ID: mdl-31446331
ABSTRACT
Vitamin D status positively relates to lean body mass in infants. This study tested the effect of vitamin D on body composition and growth-related hormones. It was hypothesized that low vitamin D status programs for higher fat mass accretion. Female weanling Sprague-Dawley rats (4 weeks; nâ¯=â¯6/diet) were randomized to AIN-93G diets with modified vitamin D contents for 8 weeks group 1 (1 IU vitamin D3/g diet), group 2 (2 IU vitamin D3/g diet), and group 3 (4 IU vitamin D3/g diet). At week 0, 4, and 8 of study, measurements included serum 25(OH)D3, IGF-1, IGFBP3, leptin, and whole body composition assessed with DXA. Differences among groups were tested using mixed model ANOVA with Tukey's post hoc t-tests. No differences were observed in baseline body composition and biomarkers, nor did body weight and food intake differ over the study. At week 8, serum 25(OH)D3 in group 3 was higher (Pâ¯<â¯.0001) compared to groups 1 and 2. At 8 weeks, lean mass (Pâ¯<â¯.05) and lean mass accretion (Pâ¯<â¯.05) were significantly higher in groups 2 and 3 compared to group 1. Serum IGF-1 concentration declined over time (Pâ¯<â¯.001) with smaller declines at week 8 in group 3 (Pâ¯<â¯.05). Serum IGFBP3 concentration was lower at week 4 in group 2 compared to groups 1 and 3. Serum leptin concentration and fat mass were not affected by diet. These results suggested that the achievement of higher vitamin D status may support a lean body phenotype without altering weight gain.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vitamina D
/
Composição Corporal
/
Dieta
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Nutr Res
Ano de publicação:
2019
Tipo de documento:
Article