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House dust mites activate nociceptor-mast cell clusters to drive type 2 skin inflammation.
Serhan, Nadine; Basso, Lilian; Sibilano, Riccardo; Petitfils, Camille; Meixiong, James; Bonnart, Chrystelle; Reber, Laurent L; Marichal, Thomas; Starkl, Philipp; Cenac, Nicolas; Dong, Xinzhong; Tsai, Mindy; Galli, Stephen J; Gaudenzio, Nicolas.
Afiliação
  • Serhan N; Unité de Différenciation Epithéliale et Autoimmunité Rhumatoïde, UMR 1056, INSERM, Université de Toulouse, Toulouse, France.
  • Basso L; Unité de Différenciation Epithéliale et Autoimmunité Rhumatoïde, UMR 1056, INSERM, Université de Toulouse, Toulouse, France.
  • Sibilano R; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
  • Petitfils C; Sean N. Parker Center for Allergy and Asthma Research, Stanford University School of Medicine, Stanford, CA, USA.
  • Meixiong J; IRSD, INSERM, INRA, INP-ENVT, Université de Toulouse 3 Paul Sabatier, Toulouse, France.
  • Bonnart C; The Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Reber LL; IRSD, INSERM, INRA, INP-ENVT, Université de Toulouse 3 Paul Sabatier, Toulouse, France.
  • Marichal T; Unit for Antibodies in Therapy and Pathology, Institut Pasteur, UMR1222 INSERM, Paris, France.
  • Starkl P; Center for Pathophysiology Toulouse Purpan, INSERM U1043, CNRS UMR 5282, Toulouse III University, Toulouse, France.
  • Cenac N; GIGA Institute and Faculty of Veterinary Medicine, Liege University, Liege, Belgium.
  • Dong X; WELBIO, Walloon Excellence in Life Sciences and Biotechnology, Wallonia, Belgium.
  • Tsai M; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
  • Galli SJ; Laboratory of Infection Biology, Department of Medicine I, Medical University of Vienna, Vienna, Austria.
  • Gaudenzio N; IRSD, INSERM, INRA, INP-ENVT, Université de Toulouse 3 Paul Sabatier, Toulouse, France.
Nat Immunol ; 20(11): 1435-1443, 2019 11.
Article em En | MEDLINE | ID: mdl-31591569
Allergic skin diseases, such as atopic dermatitis, are clinically characterized by severe itching and type 2 immunity-associated hypersensitivity to widely distributed allergens, including those derived from house dust mites (HDMs). Here we found that HDMs with cysteine protease activity directly activated peptidergic nociceptors, which are neuropeptide-producing nociceptive sensory neurons that express the ion channel TRPV1 and Tac1, the gene encoding the precursor for the neuropeptide substance P. Intravital imaging and genetic approaches indicated that HDM-activated nociceptors drive the development of allergic skin inflammation by inducing the degranulation of mast cells contiguous to such nociceptors, through the release of substance P and the activation of the cationic molecule receptor MRGPRB2 on mast cells. These data indicate that, after exposure to HDM allergens, activation of TRPV1+Tac1+ nociceptor-MRGPRB2+ mast cell sensory clusters represents a key early event in the development of allergic skin reactions.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nociceptores / Alérgenos / Pyroglyphidae / Dermatite Atópica / Mastócitos Limite: Animals / Female / Humans / Male Idioma: En Revista: Nat Immunol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: França

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nociceptores / Alérgenos / Pyroglyphidae / Dermatite Atópica / Mastócitos Limite: Animals / Female / Humans / Male Idioma: En Revista: Nat Immunol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: França