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The broad spectrum mixed-lineage kinase 3 inhibitor URMC-099 prevents acute microgliosis and cognitive decline in a mouse model of perioperative neurocognitive disorders.
Miller-Rhodes, Patrick; Kong, Cuicui; Baht, Gurpreet S; Saminathan, Priyanka; Rodriguiz, Ramona M; Wetsel, William C; Gelbard, Harris A; Terrando, Niccolò.
Afiliação
  • Miller-Rhodes P; Center for Neurotherapeutics Discovery, University of Rochester Medical Center, Rochester, NY, 14642, USA.
  • Kong C; Department of Neuroscience, University of Rochester Medical Center, Rochester, NY, 14642, USA.
  • Baht GS; Center for Translational Pain Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, NC, 27710, USA.
  • Saminathan P; Department of Orthopedic Surgery and Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, 27710, USA.
  • Rodriguiz RM; Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY, 14642, USA.
  • Wetsel WC; Department of Psychiatry and Behavioral Sciences, Mouse Behavioral and Neuroendocrine Analysis Core Facility, Duke University Medical Center, Durham, NC, 27710, USA.
  • Gelbard HA; Department of Psychiatry and Behavioral Sciences, Mouse Behavioral and Neuroendocrine Analysis Core Facility, Duke University Medical Center, Durham, NC, 27710, USA.
  • Terrando N; Departments of Neurobiology and Cell Biology, Duke University Medical Center, Durham, NC, 27710, USA.
J Neuroinflammation ; 16(1): 193, 2019 Oct 28.
Article em En | MEDLINE | ID: mdl-31660984
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridinas / Pirróis / Microglia / Assistência Perioperatória / MAP Quinase Quinase Quinases / Disfunção Cognitiva Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Neuroinflammation Assunto da revista: NEUROLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridinas / Pirróis / Microglia / Assistência Perioperatória / MAP Quinase Quinase Quinases / Disfunção Cognitiva Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Neuroinflammation Assunto da revista: NEUROLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos