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CARD 2020: antibiotic resistome surveillance with the comprehensive antibiotic resistance database.
Alcock, Brian P; Raphenya, Amogelang R; Lau, Tammy T Y; Tsang, Kara K; Bouchard, Mégane; Edalatmand, Arman; Huynh, William; Nguyen, Anna-Lisa V; Cheng, Annie A; Liu, Sihan; Min, Sally Y; Miroshnichenko, Anatoly; Tran, Hiu-Ki; Werfalli, Rafik E; Nasir, Jalees A; Oloni, Martins; Speicher, David J; Florescu, Alexandra; Singh, Bhavya; Faltyn, Mateusz; Hernandez-Koutoucheva, Anastasia; Sharma, Arjun N; Bordeleau, Emily; Pawlowski, Andrew C; Zubyk, Haley L; Dooley, Damion; Griffiths, Emma; Maguire, Finlay; Winsor, Geoff L; Beiko, Robert G; Brinkman, Fiona S L; Hsiao, William W L; Domselaar, Gary V; McArthur, Andrew G.
Afiliação
  • Alcock BP; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
  • Raphenya AR; M.G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
  • Lau TTY; Department of Biochemistry and Biomedical Science, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
  • Tsang KK; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
  • Bouchard M; M.G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
  • Edalatmand A; Department of Biochemistry and Biomedical Science, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
  • Huynh W; M.G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
  • Nguyen AV; Department of Biochemistry and Biomedical Science, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
  • Cheng AA; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
  • Liu S; M.G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
  • Min SY; Department of Biochemistry and Biomedical Science, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
  • Miroshnichenko A; M.G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
  • Tran HK; Bachelor of Health Sciences Program, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
  • Werfalli RE; M.G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
  • Nasir JA; Department of Biochemistry and Biomedical Science, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
  • Oloni M; M.G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
  • Speicher DJ; Department of Biochemistry and Biomedical Science, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
  • Florescu A; M.G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
  • Singh B; Bachelor of Health Sciences Program, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
  • Faltyn M; M.G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
  • Hernandez-Koutoucheva A; Department of Biochemistry and Biomedical Science, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
  • Sharma AN; M.G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
  • Bordeleau E; Department of Biochemistry and Biomedical Science, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
  • Pawlowski AC; M.G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
  • Zubyk HL; Department of Biochemistry and Biomedical Science, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
  • Dooley D; M.G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
  • Griffiths E; Department of Biochemistry and Biomedical Science, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
  • Maguire F; M.G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
  • Winsor GL; Department of Biochemistry and Biomedical Science, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
  • Beiko RG; M.G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
  • Brinkman FSL; Department of Biochemistry and Biomedical Science, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
  • Hsiao WWL; M.G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
  • Domselaar GV; Department of Biochemistry and Biomedical Science, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
  • McArthur AG; M.G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
Nucleic Acids Res ; 48(D1): D517-D525, 2020 01 08.
Article em En | MEDLINE | ID: mdl-31665441
ABSTRACT
The Comprehensive Antibiotic Resistance Database (CARD; https//card.mcmaster.ca) is a curated resource providing reference DNA and protein sequences, detection models and bioinformatics tools on the molecular basis of bacterial antimicrobial resistance (AMR). CARD focuses on providing high-quality reference data and molecular sequences within a controlled vocabulary, the Antibiotic Resistance Ontology (ARO), designed by the CARD biocuration team to integrate with software development efforts for resistome analysis and prediction, such as CARD's Resistance Gene Identifier (RGI) software. Since 2017, CARD has expanded through extensive curation of reference sequences, revision of the ontological structure, curation of over 500 new AMR detection models, development of a new classification paradigm and expansion of analytical tools. Most notably, a new Resistomes & Variants module provides analysis and statistical summary of in silico predicted resistance variants from 82 pathogens and over 100 000 genomes. By adding these resistance variants to CARD, we are able to summarize predicted resistance using the information included in CARD, identify trends in AMR mobility and determine previously undescribed and novel resistance variants. Here, we describe updates and recent expansions to CARD and its biocuration process, including new resources for community biocuration of AMR molecular reference data.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Software / Farmacorresistência Bacteriana / Bases de Dados Genéticas / Genes Bacterianos Tipo de estudo: Prognostic_studies / Screening_studies Idioma: En Revista: Nucleic Acids Res Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Canadá
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Software / Farmacorresistência Bacteriana / Bases de Dados Genéticas / Genes Bacterianos Tipo de estudo: Prognostic_studies / Screening_studies Idioma: En Revista: Nucleic Acids Res Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Canadá