Audiogenic Seizures in the <i>Fmr1</i> Knock-Out Mouse Are Induced by <i>Fmr1</i> Deletion in Subcortical, VGlut2-Expressing Excitatory Neurons and Require Deletion in the Inferior Colliculus.

Gonzalez, Darya; Tomasek, Madison; Hays, Seth; Sridhar, Vinay; Ammanuel, Simon; Chang, Chia-Wei; Pawlowski, Karen; Huber, Kimberly M; Gibson, Jay R

Audiogenic Seizures in the Fmr1 Knock-Out Mouse Are Induced by Fmr1 Deletion in Subcortical, VGlut2-Expressing Excitatory Neurons and Require Deletion in the Inferior Colliculus.

Gonzalez, Darya; Tomasek, Madison; Hays, Seth; Sridhar, Vinay; Ammanuel, Simon; Chang, Chia-Wei; Pawlowski, Karen; Huber, Kimberly M; Gibson, Jay R.

Afiliação

Gonzalez D; Department of Neuroscience, Dallas, and.
Tomasek M; Department of Neuroscience, Dallas, and.
Hays S; Department of Neuroscience, Dallas, and.
Sridhar V; Department of Neuroscience, Dallas, and.
Ammanuel S; Department of Neuroscience, Dallas, and.
Chang CW; Department of Neuroscience, Dallas, and.
Pawlowski K; Department of Otolaryngology and Biomedical Engineering Program, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9035.
Huber KM; Department of Neuroscience, Dallas, and Jay.Gibson@UTSouthwestern.edu Kimberly.Huber@UTSouthwestern.edu.
Gibson JR; Department of Neuroscience, Dallas, and Jay.Gibson@UTSouthwestern.edu Kimberly.Huber@UTSouthwestern.edu.

J Neurosci ; 39(49): 9852-9863, 2019 12 04.

Article em En | MEDLINE | ID: mdl-31666356

Assuntos

Epilepsia Reflexa/genética; Epilepsia Reflexa/fisiopatologia; Proteína do X Frágil da Deficiência Intelectual/genética; Colículos Inferiores/fisiopatologia; Neurônios/metabolismo; Proteína Vesicular 2 de Transporte de Glutamato/biossíntese; Animais; Síndrome do Cromossomo X Frágil/genética; Síndrome do Cromossomo X Frágil/fisiopatologia; Regulação da Expressão Gênica; Masculino; Camundongos; Camundongos Knockout; Órgão Espiral/metabolismo; Órgão Espiral/fisiopatologia; Proteína Vesicular 2 de Transporte de Glutamato/genética

Palavras-chave

Fmr1; auditory; fragile X; hypersensitivity; mouse; seizure

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Colículos Inferiores / Epilepsia Reflexa / Proteína Vesicular 2 de Transporte de Glutamato / Proteína do X Frágil da Deficiência Intelectual / Neurônios Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Neurosci Ano de publicação: 2019 Tipo de documento: Article

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