Optimization of the Codon Pair Usage of Human Respiratory Syncytial Virus Paradoxically Resulted in Reduced Viral Replication <i>In Vivo</i> and Reduced Immunogenicity.

Le Nouën, Cyril; Luongo, Cindy L; Yang, Lijuan; Mueller, Steffen; Wimmer, Eckard; DiNapoli, Joshua M; Collins, Peter L; Buchholz, Ursula J

Optimization of the Codon Pair Usage of Human Respiratory Syncytial Virus Paradoxically Resulted in Reduced Viral Replication In Vivo and Reduced Immunogenicity.

Le Nouën, Cyril; Luongo, Cindy L; Yang, Lijuan; Mueller, Steffen; Wimmer, Eckard; DiNapoli, Joshua M; Collins, Peter L; Buchholz, Ursula J.

Afiliação

Le Nouën C; Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA lenouenc@niaid.nih.gov.
Luongo CL; Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Yang L; Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Mueller S; Codagenix Inc., Stony Brook, New York, USA.
Wimmer E; Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA.
DiNapoli JM; Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Collins PL; Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Buchholz UJ; Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

J Virol ; 94(2)2020 01 06.

Article em En | MEDLINE | ID: mdl-31666376

Assuntos

Uso do Códon; Genoma Viral/imunologia; Fases de Leitura Aberta/imunologia; Infecções por Vírus Respiratório Sincicial; Vírus Sinciciais Respiratórios/fisiologia; Replicação Viral; Células A549; Animais; Anticorpos Neutralizantes/imunologia; Anticorpos Antivirais/imunologia; Chlorocebus aethiops; Cricetinae; Humanos; Mesocricetus; Camundongos; Infecções por Vírus Respiratório Sincicial/genética; Infecções por Vírus Respiratório Sincicial/imunologia; Infecções por Vírus Respiratório Sincicial/patologia; Células Vero; Replicação Viral/genética; Replicação Viral/imunologia

Palavras-chave

codon pair optimization; genome recoding; negative-strand RNA virus; respiratory syncytial virus

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus Sinciciais Respiratórios / Replicação Viral / Fases de Leitura Aberta / Genoma Viral / Infecções por Vírus Respiratório Sincicial / Uso do Códon Limite: Animals / Humans Idioma: En Revista: J Virol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos

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