Cardioprotective Effects of VCP Modulator KUS121 in Murine and Porcine Models of Myocardial Infarction.
JACC Basic Transl Sci
; 4(6): 701-714, 2019 Oct.
Article
em En
| MEDLINE
| ID: mdl-31709319
ABSTRACT
No effective treatment is yet available to reduce infarct size and improve clinical outcomes after acute myocardial infarction by enhancing early reperfusion therapy using primary percutaneous coronary intervention. The study showed that Kyoto University Substance 121 (KUS121) reduced endoplasmic reticulum stress, maintained adenosine triphosphate levels, and ameliorated the infarct size in a murine cardiac ischemia and reperfusion injury model. The study confirmed the cardioprotective effect of KUS121 in a porcine ischemia and reperfusion injury model. These findings confirmed that KUS121 is a promising novel therapeutic agent for myocardial infarction in conjunction with primary percutaneous coronary intervention.
AAR, area at risk; ATP; ATP, adenosine triphosphate; ATPase, adenosine triphosphatase; BiP, immunoglobulin heavy chain-binding protein; CHOP, C/EBP homologous protein; CMR, cardiac magnetic resonance; EF, ejection fraction; ER stress; ER, endoplasmic reticulum; FRET, fluorescence resonance energy transfer; FS, fractional shortening; H2O2, hydrogen peroxide; HF, heart failure; I/R, ischemia and reperfusion; IBMPFD, inclusion body myopathy associated with Paget's disease of bone and frontotemporal dementia; IHD, ischemic heart disease; KUS121; KUS121, Kyoto University Substance 121; LAD, left anterior descending artery; LV, left ventricular/ventricle; MI, myocardial infarction; PCI, percutaneous coronary intervention; TTC, triphenyltetrazolium chloride; TUNEL, terminal deoxynucleotidyl transferase dUTP nick-end labeling; VCP, valosin-containing protein; myocardial infarction
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
JACC Basic Transl Sci
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Japão