Disparate Central and Peripheral Effects of Circulating IGF-1 Deficiency on Tissue Mitochondrial Function.

Pharaoh, Gavin; Owen, Daniel; Yeganeh, Alexander; Premkumar, Pavithra; Farley, Julie; Bhaskaran, Shylesh; Ashpole, Nicole; Kinter, Michael; Van Remmen, Holly; Logan, Sreemathi

Pharaoh, Gavin; Owen, Daniel; Yeganeh, Alexander; Premkumar, Pavithra; Farley, Julie; Bhaskaran, Shylesh; Ashpole, Nicole; Kinter, Michael; Van Remmen, Holly; Logan, Sreemathi.

Afiliação

Pharaoh G; Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Owen D; Aging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Yeganeh A; Oklahoma Center for Geroscience, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Premkumar P; Oklahoma Center for Geroscience, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Farley J; Oklahoma Center for Geroscience, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Bhaskaran S; Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Ashpole N; Aging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Kinter M; Oklahoma Center for Geroscience, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Van Remmen H; Aging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Logan S; Oklahoma Center for Geroscience, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

Mol Neurobiol ; 57(3): 1317-1331, 2020 Mar.

Article em En | MEDLINE | ID: mdl-31732912

Assuntos

Envelhecimento/metabolismo; Encéfalo/metabolismo; Fator de Crescimento Insulin-Like I/deficiência; Mitocôndrias/metabolismo; Animais; Cognição/fisiologia; Disfunção Cognitiva/metabolismo; Modelos Animais de Doenças; Hipocampo/metabolismo; Camundongos Endogâmicos C57BL; Mitocôndrias/genética; Neurônios/metabolismo; Espécies Reativas de Oxigênio/metabolismo

Palavras-chave

Cognitive function; IGF-1; Learning and memory; Mitochondria; Oxidative stress; ROS

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Envelhecimento / Fator de Crescimento Insulin-Like I / Mitocôndrias Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Mol Neurobiol Assunto da revista: BIOLOGIA MOLECULAR / NEUROLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos

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