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Percutaneous Interstitial Nd:YAG Laser Therapy for Axillary Osmidrosis.
Geng, Yu-Jia; Li, Tian; Wen, Lei; Gao, Hai; Yuan, Ju; Liu, Wei-Chi; Shao, Ying.
Afiliação
  • Geng YJ; Department of Plastic and Reconstructive Surgery, The First Hospital of Jilin University, Changchun, Jilin, China.
  • Li T; Department of Plastic and Reconstructive Surgery, The First Hospital of Jilin University, Changchun, Jilin, China.
  • Wen L; Department of Plastic and Reconstructive Surgery, The First Hospital of Jilin University, Changchun, Jilin, China.
  • Gao H; Department of Plastic and Reconstructive Surgery, The First Hospital of Jilin University, Changchun, Jilin, China.
  • Yuan J; Department of Plastic and Reconstructive Surgery, The First Hospital of Jilin University, Changchun, Jilin, China.
  • Liu WC; Department of Plastic and Reconstructive Surgery, The First Hospital of Jilin University, Changchun, Jilin, China.
  • Shao Y; Department of Plastic and Reconstructive Surgery, The First Hospital of Jilin University, Changchun, Jilin, China.
Lasers Surg Med ; 52(7): 639-646, 2020 09.
Article em En | MEDLINE | ID: mdl-31736126
ABSTRACT
BACKGROUND AND

OBJECTIVES:

To investigate the effects of percutaneous interstitial NdYAG laser irradiation on the apocrine glands and molecules involved in odor production (apolipoprotein [ApoD], androgen receptor [AR]) in the subcutaneous tissue of a pig. STUDY DESIGN/MATERIALS AND

METHODS:

Skin on the back of healthy adult miniature pigs was exposed to pulsed NdYAG laser irradiation at 5 or 10 W, or continuous NdYAG laser irradiation at 10 W. Samples were taken 1 hour, 1 week, and 1 month after treatment for histology, western blot, and real-time quantitative polymerase chain reaction (qRT-PCR) analysis.

RESULTS:

One week and 1 month after irradiation, the apocrine glands in pigskin became rounded, glandular cells were shorter, and the glandular cavities were larger compared with controls, but there were no obvious changes in fat cell distribution of collagen around the apocrine glands. One month after irradiation at 10 W in continuous mode, there was a significant decrease in ApoD expression in apocrine cells and ApoD and AR protein and expression levels in pigskin compared with controls. There were also significant differences in ApoD and AR protein and expression levels between treatments.

CONCLUSIONS:

Percutaneous interstitial NdYAG laser irradiation has potential as a safe and efficacious treatment for axillary osmidrosis as it may decrease the production of volatile unsaturated fatty acids, steroids, and associated unpleasant odors in the axilla. Lasers Surg. Med. © 2019 Wiley Periodicals, Inc.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Terapia a Laser / Lasers de Estado Sólido Limite: Animals Idioma: En Revista: Lasers Surg Med Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Terapia a Laser / Lasers de Estado Sólido Limite: Animals Idioma: En Revista: Lasers Surg Med Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China