Methemoglobin and the response to inhaled nitric oxide in persistent pulmonary hypertension of the newborn.
J Neonatal Perinatal Med
; 13(2): 175-182, 2020.
Article
em En
| MEDLINE
| ID: mdl-31744017
ABSTRACT
BACKGROUND:
We aimed to investigate whether the change in methemoglobin levels (ΔMHb) predicts oxygenation response to inhaled nitric oxide (iNO) in persistent pulmonary hypertension of the newborn (PPHN) with lung disease, with or without pulmonary hypoplasia.METHODS:
In this prospective observational study, infants were categorized based on ΔMHb and oxygenation response (ΔPaO2/FiO2) following iNO ΔMHb ≤0 or ΔMHb>0, and ΔPaO2/FiO2â<â20âmmHg (Non-responder) or≥20âmmHg (Responder). ΔMHb levels were compared among infants with or without pulmonary hypoplasia.RESULTS:
Among infants with pulmonary hypoplasia (nâ=â28), ΔMHb was not associated with an oxygenation response to iNO or survival without ECMO. Among infants without hypoplasia (nâ=â29), subjects with ΔMHb>0 following iNO (nâ=â21) had a greater ΔPaO2/FiO2 (median, 64âmmHg; IQR, 127; pâ<â0.01) and 100% survival without extracorporeal membrane oxygenation (ECMO) when compared to infants with ΔMHb ≤0 (nâ=â8; median 10âmmHg; IQR, 33).CONCLUSIONS:
PPHN secondary to lung disease without hypoplasia with increased ΔMHb following iNO was associated with better oxygenation response and survival without ECMO compared to subjects without an increase in MHb.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Síndrome da Persistência do Padrão de Circulação Fetal
/
Metemoglobina
/
Fatores Relaxantes Dependentes do Endotélio
/
Óxido Nítrico
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Female
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Humans
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Male
/
Newborn
/
Pregnancy
Idioma:
En
Revista:
J Neonatal Perinatal Med
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Estados Unidos